Publications:

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  1. Homosolvolysis.
    Low, H.; Paterson, I.; Tedder, J. M.; Walton, J. C. J. Chem. Soc., Chem. Commun. 1977, 171-172. Link to Publication
  2. t-Butylation of aldehydes and ketones by the Friedel-Crafts alkylation of trimethylsilyl enol ethers.
    Chan, T. H.; Paterson, I.; Pinsonnault, J. Tetrahedron Lett. 1977, 4183-4186.
  3. Free radical addition to olefins. Part 23. Kinetics of the addition of chloroiodomethane to ethylene and vinyl fluoride.
    Paterson, I.; Tedder, J. M.; Walton, J. C. J. Chem. Soc., Perkin Trans. II 1978, 884- 887. Link to Publication
  4. Methylenation of lactones and esters: zinc bromide catalysed phenylthiomethylation of O-silylated enolates.
    Paterson, I.; Fleming, I. Tetrahedron Lett. 1979, 993-994. Link to Publication
  5. Regiospecific α-methylenation and α-methylation of ketones: titanium tetrachloride- promoted phenylthiomethylation of silyl enol ethers.
    Paterson, I.; Fleming, I. Tetrahedron Lett. 1979, 995-998. Link to Publication
  6. α-Alkylation of ketones, esters, and lactones: zinc bromide catalysed alkylation of O-silylated enolates, a synthesis of (±)-ar-turmerone.
    Paterson, I. Tetrahedron Lett. 1979, 1519-1520.
  7. α-Alkylation and α-alkylidenation of carbonyl compounds: Lewis acid-promoted phenylthioalkylation of O-silylated enolates.
    Paterson, I.; Fleming, I. Tetrahedron Lett. 1979, 2179-2182.
  8. Allylsilanes in organic synthesis: a method for the introduction of two carbon substituents in place of carbonyl oxygen.
    Fleming, I.; Paterson, I. Synthesis1979, 446-448.
  9. γ-Sulphenylation of β-unsaturated aldehydes, ketones, and esters: the use of O -silylated dienolates.
    Fleming, I.; Goldhill, J.; Paterson, I. Tetrahedron Lett. 1979, 3205-3208.
  10. γ-Alkylation of unsaturated ketones and esters: zinc bromide catalysed alkylation of O-silylated dienolates.
    Fleming, I.; Goldhill, J.; Paterson, I. Tetrahedron Lett. 1979, 3209-3212.
  11. A simple synthesis of carvone using silyl enol ethers.
    Fleming, I.; Paterson, I. Synthesis 1979, 736-738.
  12. The formation of allyl sulphides by phenylthio-migration: control by silicon.
    Fleming, I.; Paterson, I.; Pearce, A. J. Chem. Soc., Perkin Trans. I 1981, 256-262. Link to Publication
  13. O-Silylated enolates in organic synthesis: α-alkylation of carbonyl compounds by 1,3-dithienium fluoroborate.
    Paterson, I.; Price, L. G. Tetrahedron Lett. 1981, 22, 2829-2832.
  14. O-Silylated dienolates in organic synthesis: γ-selective alkylation of unsaturated carbonyl compounds by 1,3-dithienium fluoroborate.
    Paterson, I.; Price, L. G. Tetrahedron Lett. 1981, 22, 2833-2836.
  15. O-Silylated enolate phenylthioalkylation: a new synthesis of unsaturated 1,5- dicarbonyl compounds.
    Khan, H. A.; Paterson, I. Tetrahedron Lett. 1982, 23, 2399-2402.
  16. O-Silylated enolate phenylthioalkylation: a synthesis of α,β-unsaturated 5- and 6- membered lactones.
    Khan, H. A.; Paterson, I. Tetrahedron Lett. 1982, 23, 5083-5086.
  17. A stereoselective synthesis of the chiral sequence of erythronolide A.
    Stork, G.; Paterson, I.; Lee, F. K. C. J. Am. Chem. Soc. 1982, 104, 4686-4688.Link to Publication
  18. O-Silylated enolates in organic synthesis: sulphur-mediated alkylation of esters with alkenes.
    Patel, S. K.; Paterson, I. Tetrahedron Lett. 1982, 24, 1315-1318.
  19. Studies in macrolide synthesis: a synthesis of two chiral fragments of oleandomycin and lankamycin.
    Paterson, I. Tetrahedron Lett. 1983,24, 1311-1314.
  20. Studies in macrolide synthesis; an efficient synthesis of two chiral fragments of erythronolide A.
    Paterson, I.; Patel, S. K.; Porter, J. R. Tetrahedron Lett. 1983, 24, 3395-3396.
  21. Alkene carbosulphenylation and carboselenylation: the use of allyltrimethylsilane and O-silylated enolates.
    Alexander, R. P.; Paterson, I. Tetrahedron Lett. 1983, 24, 5911-5914.
  22. Preparation of tritium-labelled meta-aminolevamisole of high specific radioactivity by catalytic dehalogenation.
    Lewis, J. A.; Paterson, I. J. Labelled Compounds and Radiopharmaceuticals 1984, 21, 945-959.
  23. Recent developments in the total synthesis of macrolide antibiotics.
    Paterson, I.; Mansuri, M. M. Tetrahedron 1985, 41, 3569-3624.
  24. Asymmetric alkylation and sulphenylation of chiral O-silylated imide enolates.
    Alexander, R. P.; Paterson, I. Tetrahedron Lett. 1985, 26, 5339-5340.
  25. Enantioselective aldol condensations: the use of ketone boron enolates with chiral ligands attached to boron.
    Paterson, I.; Lister, M. A.; McClure, C. K. Tetrahedron Lett. 1986, 27, 4787-4790.
  26. Studies in macrolide synthesis: aldol condensations of chiral ethyl ketones via boron enolates.
    Paterson, I.; McClure, C. K. Tetrahedron Lett. 1987, 28, 1229-1232.
  27. Studies in polyether synthesis using polyepoxide cyclisations.
    Paterson, I.; Boddy, I.; Mason, I. Tetrahedron Lett. 1987, 28, 5205-5208.
  28. A force field model for boron enolates.
    Goodman, J. M.; Paterson, I.; Kahn, S. D. Tetrahedron Lett. 1987, 28, 5209-5212.
  29. Degradation of oleandomycin: controlled removal of sugars to give oleandolide C3,C5-acetonide.
    Paterson, I.; Arya, P. Tetrahedron 1988, 44, 253-260.
  30. α-Alkylation and α-alkylidenation of carbonyl compounds by O-silylated enolate phenylthioalkylation.
    Paterson, I. Tetrahedron 1988, 44, 4207-4219.
  31. Aldol condensations of chiral ethyl ketones: control by chiral boron reagents.
    Paterson, I.; Lister, M. A. Tetrahedron Lett. 1988, 29, 585-588.
  32. Studies in macrolide synthesis: a concise asymmetric synthesis of a macrolide intermediate for the erythronolides.
    Paterson, I.; Laffan, D. D. P.; Rawson, D. J. Tetrahedron Lett. 1988, 29, 1461-1464.
  33. New asymmetric aldol methodology using boron enolates.
    Paterson, I. Chemistry and Industry (London) 1988, 390-394.
  34. Studies in polyether synthesis: spiroacetal formation by directed bisepoxide cyclisation.
    Paterson, I.; Boddy, I. Tetrahedron Lett. 1988, 29, 5301-5304. Link to Publication
  35. Aldol reactions of methyl ketones using chiral boron reagents: a reversal in aldehyde enantioface selectivity.
    Paterson, I.; Goodman, J. M. Tetrahedron Lett. 1989, 30, 997-1000. Link to Publication
  36. A short asymmetric synthesis of a C19-C27 segment of rifamycin S. Kinetic resolution in the aldol reactions of ethyl ketones using chiral boron reagents.
    Paterson, I.; McClure, C. K.; Schumann, R. C. Tetrahedron Lett. 1989, 30, 1293-1296. Link to Publication
  37. Studies in marine cembranolide synthesis: a synthesis of 2,3,5-trisubstituted furan intermediates for lophotoxin and pukalide.
    Paterson, I.; Gardner, M.; Banks, B. J. Tetrahedron 1989, 45, 5283-5286. Link to Publication
  38. Studies in polyether synthesis: controlled bisepoxide cyclisation using a β-diketone group.
    Paterson, I.; Craw, P. A. Tetrahedron Lett. 1989, 30, 5799-5802.
  39. Aldol reactions in polypropionate synthesis: high π-face selectivity of enol borinates from α-chiral methyl and ethyl ketones under substrate control.
    Paterson, I.; Goodman, J. M; Isaka, M. Tetrahedron Lett. 1989, 30, 7121-7124.
  40. Studies in macrolide synthesis: a highly stereoselective synthesis of (+)-(9S)- dihydroerythronolide A using macrocyclic stereocontrol.
    Paterson, I.; Rawson, D. J. Tetrahedron Lett. 1989, 30, 7463-7466.
  41. Theoretical studies of aldol stereoselectivity: the development of a force field model for enol borinates and the investigation of chiral enolate π-face selectivity.
    Goodman, J. M.; Kahn, S. D.; Paterson, I. J. Org. Chem. 1990, 55, 3295-3303. Link to Publication
  42. Transition state modelling of the aldol reaction of boron enolates: a force field approach.
    Bernardi, A.; Capelli, A. M.; Gennari, C.; Goodman, J. M.; Paterson, I. J. Org. Chem. 1990, 55, 3576-3581. Link to Publication
  43. Stereoselective aldol reactions of β-chlorovinyl ketones using dienol borinates: a new synthesis of dihydropyrones.
    Paterson, I.; Osborne, S. A. Tetrahedron Lett. 1990, 31, 2213-2216. Link to Publication
  44. Enantio- and diastereoselective aldol reactions of achiral ethyl and methyl ketones with aldehydes: the use of enol diisopinocampheylborinates.
    Paterson, I.; Goodman, J. M.; Lister, M. A.; Schumann, R. C.; McClure, C. K.; Norcross, R. D. Tetrahedron 1990, 46, 4663-4684. Link to Publication
  45. Total synthesis of the esterase inhibitor (±)-ebelactone A using an aldol-Claisen strategy.
    Paterson, I.; Hulme, A. N. Tetrahedron Lett. 1990, 31, 7513-7516. Link to Publication
  46. Origins of stereoselectivity in chiral boron enolate aldol reactions: a computational study using transition state modelling.
    Bernardi, A.; Capelli, A. M.; Comotti, A.; Gennari, C.; Gardner, M.; Goodman, J. M.; Paterson, I. Tetrahedron 1991,47, 3471-3484. Link to Publication
  47. Asymmetric aldol reactions using chiral boron reagents: application to the synthesis of tirandamycin A.
    Paterson, I.; Lister, M. A.; Ryan, G. R. Tetrahedron Lett. 1991, 32, 1749-1752. Link to Publication
  48. Enol borinates in organic synthesis: regioselective α-sulphenylation and α-selenenylation of ketones.
    Paterson, I.; Osborne, S. Synlett 1991, 2, 145-146. Link to Publication
  49. The aldol reaction for transition metal enolates.
    Paterson, I. Comprehensive Organic Synthesis: Selectivity for Synthetic Efficiency, Trost, B. M., Ed., Vol. 2, pp 301-319, Pergamon Press, Oxford, 1991.
  50. Stereocontrolled, two-directional, chain synthesis using the boron aldol reaction and double Ireland-Claisen rearrangement.
    Paterson, I.; Hulme, A. N.; Wallace, D. J. Tetrahedron Lett. 1991, 32, 7601-7604. Link to Publication
  51. Studies in polypropionate synthesis: a general approach to the synthesis of stereopentads.
    Paterson, I.; Channon, J. A. Tetrahedron Lett. 1992, 33, 797-800.
  52. Studies in polypropionate synthesis: stereocontrolled synthesis of (-)-denticulatins A and B.
    Paterson, I.; Perkins, M. V. Tetrahedron Lett. 1992, 33, 801-804. Link to Publication
  53. Studies in macrolide synthesis: a stereocontrolled synthesis of a (9S)-macrolide intermediate for oleandomycin using chiral boron reagents.
    Paterson, I.; Lister, M. A.; Norcross, R. D. Tetrahedron Lett. 1992, 33, 1767-1770. Link to Publication
  54. A stereocontrolled synthesis of a C19-C32 / C17-C30 segment for swinholide A and misakinolide A, cytotoxic dimeric macrolides from Theonella swinhoei.
    Paterson, I.; Cumming, J. G. Tetrahedron Lett. 1992, 33, 2847-2850. Link to Publication
  55. Developing a force field for the transition state of the aldol reaction of enolborinates: evaluation of the use of fixed point charges.
    Bernardi, A.; Cassinari, A.; Comotti, A.; Gardner, M.; Gennari, C.; Goodman, J.; Paterson, I. Tetrahedron1992, 48, 4183-4192. Link to Publication
  56. Diastereofacial selectivity in the aldol reactions of chiral α-methyl aldehydes: a computer modelling approach.
    Gennari, C.; Vieth, S.; Comotti, A.; Vulpetti, A.; Goodman, J. M.; Paterson, I. Tetrahedron 1992, 48, 4439-4458. Link to Publication
  57. Stereocontrolled synthesis of a C1-C15 segment for the marine macrolides, swinholide A and scytophycin C: use of a vinylogous Mukaiyama aldol reaction.
    Paterson, I.; Smith, J. D. J. Org. Chem.1992, 57, 3261-3264. Link to Publication
  58. Studies in polypropionate synthesis: high π-face selectivity in syn aldol reactions of Sn(II) enolates from (R)- and (S)-1-(benzyloxy)-2-methylpentan-3-one.
    Paterson, I.; Tillyer, R. D. Tetrahedron Lett. 1992, 33, 4233-4236. Link to Publication
  59. The rational design of highly stereoselective boron enolates using transition-state computer modelling: a novel, asymmetric anti aldol reaction for ketones.
    Gennari, C.; Hewkin, C. T.; Molinari, F.; Bernardi, A.; Comotti, A.; Goodman, J. M.; Paterson, I. J. Org. Chem. 1992, 57, 5173-5177. Link to Publication
  60. New methods and strategies for the stereocontrolled synthesis of polypropionate- derived natural products.
    Paterson, I. Pure Appl. Chem. 1992, 64, 1821-1830.
  61. Meso epoxides in asymmetric synthesis. Enantioselective opening by nucleophiles in the presence of chiral Lewis acids.
    Paterson, I.; Berrisford, D. J. Angew. Chem., Int. Ed. Eng. 1992, 31, 1179-1180. Angew. Chem. 1992, 104, 1204-1205. Link to Publication
  62. Enolisation of ketones by dialkylboron chlorides and triflates: a model for the effect of reagent leaving group, substrate structure and amine base.
    Goodman, J. M.; Paterson, I. Tetrahedron Lett. 1992, 33, 7223-7226. Link to Publication
  63. Origins of π-face selectivity in the aldol reactions of chiral E-enol borinates: a computational study using transition state modelling.
    Vulpetti, A.; Bernardi, A.; Gennari, C.; Goodman, J. M.; Paterson, I. Tetrahedron 1993, 49, 685-696. Link to Publication
  64. Origins of stereoselectivity in the addition of chiral allyl- and crotylboranes to aldehydes: The development and application of a force field model of the transition state.
    Vulpetti, A.; Gardner, M.; Gennari, C.; Bernardi, A.; Goodman, J. M.; Paterson, I. J. Org. Chem. 1993, 58, 1711-1718. Link to Publication
  65. Total synthesis of the marine polypropionate (+)-muamvatin. A configurational model for Siphonariid metabolites.
    Paterson, I; Perkins, M. V. J. Am. Chem. Soc. 1993, 115, 1608-1610. Link to Publication
  66. Studies in biomimetic polyether synthesis: synthesis of an A-ring subunit of etheromycin.
    Paterson, I.; Tillyer, R. D.; Ryan, G. R. Tetrahedron Lett. 1993, 34, 4389-4392. Link to Publication
  67. 1,3-Asymmetric induction in the aldol reactions of α-methylene, β-alkoxy aldehydes.
    Paterson, I.; Bower, S.; Tillyer, R. D. Tetrahedron Lett. 1993, 34, 4393-4396. Link to Publication
  68. High π-face selectivity in anti aldol reactions of E-enol borinates from chiral alkoxymethyl ketones: stereocontrolled synthesis of a C24-C32 polyol subunit of rapamycin.
    Paterson, I.; Tillyer, R. D. J. Org. Chem. 1993, 58, 4182-4184. Link to Publication
  69. Studies in marine macrolide synthesis: a stereocontrolled synthesis of a C17-C32 subunit of scytophycin C.
    Paterson, I.; Yeung, K.-S. Tetrahedron Lett. 1993, 34, 5347-5350. Link to Publication
  70. Studies in marine macrolide synthesis: asymmetric synthesis of C1-C15/C16 subunits of swinholide A and scytophycin C.
    Paterson, I.; Smith, J. D. Tetrahedron Lett. 1993, 34, 5351-5354. Link to Publication
  71. The Horner-Wadsworth-Emmons reaction in natural products synthesis: expedient construction of complex (E)-enones using barium hydroxide.
    Paterson, I.; Yeung, K.-S.; Smaill, J. B. Synlett 1993, 774-776. Link to Publication
  72. Studies in biomimetic polyether synthesis: construction of an ABCD-ring subunit of etheromycin using polyepoxide cascade cyclisations.
    Paterson, I.; Tillyer, R. D.; Smaill, J. B. Tetrahedron Lett. 1993, 34, 7137-7140. Link to Publication
  73. Studies towards the total synthesis of the marine-derived immunosuppressant discodermolide. Asymmetric synthesis of a C1-C8 δ-lactone subunit.
    Paterson, I.; Wren, S. P. J. Chem. Soc., Chem. Commun. 1993, 1790-1793.
  74. Computer-assisted design of chiral boron enolates: the role of ate complexes in determining aldol stereoselectivity.
    Bernardi, A.; Comotti, A.; Gennari, C.; Hewkin, C. T.; Goodman, J. M.; Schlapbach, A.; Paterson, I. Tetrahedron 1994, 50, 1227-1242. Link to Publication
  75. Studies in marine macrolide synthesis: boron and silicon-mediated coupling strategies for swinholide A.
    Paterson, I.; Cumming, J. G.; Smith, J. D.; Ward, R. A. Tetrahedron Lett. 1994, 35, 441-444. Link to Publication
  76. Total synthesis of (-)-preswinholide A.
    Paterson, I.; Smith, J. D.; Ward, R. A.; Cumming, J. G. J. Am. Chem. Soc. 1994, 116, 2615-2616. Link to Publication
  77. Substrate controlled aldol reactions of chiral ethyl ketones: application to the total synthesis of oleandomycin.
    Paterson, I.; Ward, R. A.; Romea, P.; Norcross, R. D. J. Am. Chem. Soc. 1994, 116, 3623-3624. Link to Publication
  78. Towards the synthesis of swinholide A and scytophycin C. A highly stereocontrolled synthesis of (-)-pre-swinholide A.
    Paterson, I.; Cumming, J. G.; Smith, J. D.; Ward, R. A.; Yeung, K.-S. Tetrahedron Lett. 1994, 35, 3405-3408. Link to Publication
  79. Total synthesis of swinholide A and hemiswinholide A.
    Paterson, I.; Yeung, K.-S.; Ward, R. A.; Cumming, J. G.; Smith, J. D. J. Am. Chem. Soc. 1994, 116, 9391-9392. Link to Publication
  80. Recent developments in asymmetric aldol methodology.
    Franklin, A. S.; Paterson, I. Contemp. Org. Synth. 1994, 1, 317-338. Link to Publication
  81. Assignment of the absolute configuration of the siphonarins and baconipyrones. Enantiocontrolled synthesis of a γ-pyrone subunit.
    Paterson, I.; Franklin, A. S. Tetrahedron Lett. 1994, 35, 6925-6928. Link to Publication
  82. A configurational model for siphonariid polypropionates derived from structural and biosynthetic considerations.
    Garson, M. J.; Goodman, J. M.; Paterson, I. Tetrahedron Lett. 1994, 35, 6929-6932.
  83. Studies in polypropionate synthesis: high π-face selectivity in syn and anti aldol reactions of chiral boron enolates of lactate-derived ketones.
    Paterson, I.; Wallace, D. J.; Velazquez, S. M. Tetrahedron Lett. 1994, 35, 9083-9086. Link to Publication
  84. Manipulation of the aldol adducts from lactate-derived ketones. A versatile chiral auxiliary for the asymmetric synthesis of β-hydroxy carbonyl compounds.
    Paterson, I.; Wallace, D. J. Tetrahedron Lett. 1994, 35, 9087-9090. Link to Publication
  85. Studies in macrolide synthesis: Synthesis of oleandolide using substrate- and reagent-controlled aldol reactions of (S)-1-(benzyloxy)-2-methylpentan-3-one.
    Paterson, I.; Norcross, R. D.; Ward, R. A.; Romea, P.; Lister, M. A. J. Am. Chem. Soc. 1994, 116, 11287-11314. Link to Publication
  86. Anti aldol reactions of lactate-derived ketones. Application to the total synthesis of (-)-ACRL Toxin IIIB.
    Paterson, I.; Wallace, D. J. Tetrahedron Lett. 1994, 35, 9477-9480. Link to Publication
  87. Stereocontrolled aldol additions to α-methylene-β-alkoxy aldehydes. Application to the synthesis of a C13-C25 segment of bafilomycin A1.
    Paterson, I.; Bower, S.; McLeod, M. D. Tetrahedron Lett. 1995, 36, 175-178. Link to Publication
  88. Mechanistic insights from ab initio calculations on a nitrogen analogue of the boron- mediated aldol reaction.
    Bernardi, A.; Gennari, C.; Goodman, J. M.; Leue, V.; Paterson, I. Tetrahedron 1995, 51, 4853-4866. Link to Publication
  89. Total synthesis of (-)-ebelactone A and B.
    Paterson, I.; Hulme, A. N.J. Org. Chem. 1995, 60, 3288-3300. Link to Publication
  90. Studies towards the total synthesis of the marine-derived immunosuppressant discodermolide. Stereoselective synthesis of a C9-C24 subunit.
    Paterson, I.; Schlapbach, A. Synlett 1995, 498-500. (Gilbert Stork Special Issue)
  91. The total synthesis of swinholide A. Part 1: A stereocontrolled synthesis of a C19-C32 segment.
    Paterson, I.; Cumming, J. G.; Ward, R. A.; Lamboley, S. Tetrahedron 1995, 51, 9393-9412. Link to Publication
  92. The total synthesis of swinholide A. Part 2: A stereocontrolled synthesis of a C1-C15 segment.
    Paterson, I.; Smith, J. D. Ward, R. A. Tetrahedron1995, 51, 9413-9436. Link to Publication
  93. The total synthesis of swinholide A. Part 3: Fragment coupling studies leading to a stereocontrolled synthesis of (-)-pre-swinholide A.
    Paterson, I.; Ward, R. A.; Smith, J. D.; Cumming, J. G.; Yeung, K.-S. Tetrahedron 1995, 51, 9437-9466. Link to Publication
  94. The total synthesis of swinholide A. Part 4: Synthesis of swinholide A and iso-swinholide A from a protected version of the monomeric seco acid, pre-swinholide A.
    Paterson, I.; Yeung, K.-S.; Ward, R. A.; Smith, J. D.; Cumming, J. G.; Lamboley, S. Tetrahedron 1995, 51, 9467-9486. Link to Publication
  95. Total synthesis of bioactive marine macrolides.
    Norcross, R. D.; Paterson, I. Chem. Rev. 1995, 95, 2041-2114. Link to Publication
  96. A computational model for stereoselectivity in the boron-mediated aldol reactions of methyl ketones.
    Bernardi, A.; Gennari, C.; Goodman, J. M.; Paterson, I. Electronic Conference on Trends in Organic Chemistry (ECTOC-1), 1995, Eds. Rzepa, H.S., Goodman, J. M. (CD-ROM), Royal Society of Chemistry publications.
  97. The rational design and systematic analysis of asymmetric aldol reactions using enol borinates: applications of transition state computer modelling.
    Bernardi, A.; Gennari, C.; Goodman, J. M.; Paterson, I. Tetrahedron: Asymmetry 1995, 6, 2613-2636.
  98. Studies in macrolide synthesis: a sequential aldol / glycosylation approach to the synthesis of concanamycin A.
    Paterson, I.; McLeod, M. D. Tetrahedron Lett. 1995, 36, 9065-9068. Link to Publication
  99. Total synthesis of (-)-denticulatins A and B using efficient methods of acyclic stereocontrol.
    Paterson, I.; Perkins, M. V. Tetrahedron1996, 52, 1811-1834. Link to Publication
  100. Two complementary methods for the synthesis of the terminal N-alkenyl-N- methylformamide group found in cytotoxic marine macrolides.
    Paterson, I.; Cowden, C.; Watson, C. Synlett 1996, 209-211. Link to Publication
  101. Anti aldol reactions of α-alkoxymethyl ketones: application to the total synthesis of (+)-restricticin.
    Paterson, I.; Nowak, T. Tetrahedron Lett. 1996, 37, 8243-8246. Link to Publication
  102. Studies in marine macrolide synthesis: stereocontrolled synthesis of the AB- spiroacetal subunit of spongistatin 1 (altohyrtin A).
    Paterson, I.; Oballa, R. M.; Norcross, R. D. Tetrahedron Lett. 1996, 37, 8581-8584. Link to Publication
  103. Remote, 1,5-anti stereoinduction in the boron-mediated aldol reactions of β- oxygenated methyl ketones.
    Paterson, I.; Gibson. K. R.; Oballa, R. M. Tetrahedron Lett. 1996, 37, 8585-8588 Link to Publication.
  104. Studies towards the synthesis of the zaragozic acids: a novel epoxide cyclisation approach to the formation of the bicyclic acetal core.
    Paterson, I.; Feβner, K.; Finlay, M. R. V.; Jacobs, M. F. Tetrahedron Lett. 1996, 37, 8803-8806. Link to Publication
  105. Total Synthesis of Scytophycin C.
    Paterson, I.; Watson, C.; Yeung, K.-S.; Wallace, P. A.; Ward, R. A. J. Org. Chem. 1997, 62, 452-453. Link to Publication
  106. Studies in macrolide synthesis: a novel cyclodimerisation approach to the synthesis of elaiophylin using a double Stille cross-coupling reaction.
    Paterson, I.; Man, J. Tetrahedron Lett. 1997, 38, 695-698. Link to Publication
  107. Erythromycin Derivatives.
    Paterson, I. UK Patent Application 9700702.5. 15 Jan 1997.
  108. Asymmetric aldol reactions using boron enolates.
    Cowden, C. J.; Paterson, I. Organic Reactions 1997, 51, 1-200.
  109. Studies in macrolide synthesis: Stereocontrolled synthesis of a C1-C13 segment of concanamycin A.
    Paterson, I.; McLeod, M. D. Tetrahedron Lett. 1997, 38, 4183-4186. Link to Publication
  110. Studies towards the synthesis of the zaragozic acids: synthesis of the bicyclic acetal core of zaragozic acid C.
    Paterson, I.; Feβner, K.; Finlay, M. R. V. Tetrahedron Lett. 1997, 38, 4301-4304. Link to Publication
  111. Cancer drugs better than Taxol?
    Cowden, C. J.; Paterson, I. Nature 1997, 387, 238-239. Link to Publication
  112. Studies in marine macrolide synthesis: stereocontrolled synthesis of the F-ring subunit of spongistatin 1 (altohyrtin A).
    Paterson, I.; Keown, L. E. Tetrahedron Lett. 1997, 38, 5727-5730. Link to Publication
  113. Polyketide library synthesis: iterative assembly of extended polypropionates using (R)- and (S)-1-(benzyloxy)-2-methylpentan-3-one.
    Paterson, I.; Scott. J. P. Tetrahedron Lett. 1997, 38, 7441-7444. Link to Publication
  114. Polyketide library synthesis: conformational control in extended polypropionates.
    Paterson, I.; Scott. J. P. Tetrahedron Lett. 1997, 38, 7445-7448. Link to Publication
  115. Studies in marine macrolide synthesis: synthesis of the C1-C15 subunit of spongistatin 1 (altohyrtin A) and 15,16-anti aldol coupling reactions.
    Paterson, I.; Oballa, R. M. Tetrahedron Lett. 1997, 38, 8241-8244. Link to Publication
  116. Studies in marine macrolide synthesis: synthesis of a C16-C28 subunit of spongistatin 1 (altohyrtin A) incorporating the CD-spiroacetal moiety.
    Paterson, I.; Wallace, D. J.; Gibson, K. R. Tetrahedron Lett. 1997, 38, 8911-8914. Link to Publication
  117. Polyketide synthesis using the boron-mediated, anti-aldol reactions of lactate-derived ketones: total synthesis of (-)-ACRL Toxin IIIB.
    Paterson, I.; Wallace, D. J.; Cowden, C. J. Synthesis 1998, 639-652. (Symposium-In-Print on Natural Products Synthesis)
  118. Epoxides in asymmetric synthesis. Enantioselective opening by nucleophiles promoted by chiral transition metal complexes.
    Paterson, I.; Berrisford, D. J. Organic Synthesis Highlights, Vol III, Mulzer, J., Waldmann, H., Eds., pp 62-66, Wiley-VCH, Weinheim, 1998.
  119. The total synthesis of scytophycin C. Part 1: Stereocontrolled synthesis of the protected C1-C32 seco acid.
    Paterson, I.; Yeung, K.-S.; Watson, C.; Ward, R. A.; Wallace, P. A. Tetrahedron 1998, 54, 11935-11954. Link to Publication
  120. The total synthesis of scytophycin C. Part 2: Synthesis of scytophycin C from the protected seco acid.
    Paterson, I.; Watson, C.; Yeung, K.-S.; Ward, R. A.; Wallace, P. A. Tetrahedron 1998, 54, 11955-11970. Link to Publication
  121. A facile oxidation/deprotection of electron rich silyl ethers using DDQ.
    Paterson, I.; Cowden, C. J.; Rahn, V. S.; Woodrow, M. D. Synlett 1998, 915-917. Link to Publication
  122. Studies in marine macrolide synthesis: stereocontrolled synthesis of the C1-C11 and C15-C27 subunits of aplyronine A.
    Paterson, I.; Cowden, C. J.; Woodrow, M. D. Tetrahedron Lett. 1998, 39, 6037-6040. Link to Publication
  123. Studies in marine macrolide synthesis: construction of a 24-membered macrocyclic intermediate for aplyronine A.
    Paterson, I.; Woodrow, M. D.; Cowden, C. J. Tetrahedron Lett. 1998, 39, 6041-6044. Link to Publication
  124. Towards the total synthesis of phorboxazoles A and B: stereocontrolled synthesis of a C20-C32 subunit.
    Paterson, I.; Arnott, E. A. Tetrahedron Lett. 1998, 39, 7185-7188. Link to Publication
  125. Studies in marine macrolide synthesis: synthesis of a fully functionalised C1-C28 subunit of spongistatin 1 (altohyrtin A).
    Paterson, I.; Wallace, D. J.; Oballa, R. M. Tetrahedron Lett. 1998, 39, 8545-8548. Link to Publication
  126. Stereocontrolled synthesis of polyketide libraries: boron-mediated aldol reactions with aldehydes on solid support.
    Gennari. C.; Ceccarelli, S.;Piarulli, U.;Aboutayab, K.;Donghi, M.; Paterson, I. Tetrahedron 1998, 54, 14999-15016. Link to Publication
  127. Anti aldol reactions of lactate-derived ketones. Application to the total synthesis of (-)-tetrahydrolipstatin.
    Paterson, I.; Doughty, V. A. Tetrahedron Lett. 1999, 40, 393-394. Link to Publication
  128. Laboratory emulation of polyketide biosynthesis: an iterative, aldol-based, synthetic entry to polyketide libraries using (R)- and (S)-1-(benzyloxy)-2- methylpentan-3-one, and conformational aspects of extended polypropionates.
    Paterson, I.; Scott, J. P. J. Chem. Soc., Perkin Trans. 1 1999, 1003-1014. Link to Publication
  129. Total synthesis of elaiolide using a copper(I)-promoted Stille cyclodimerization reaction.
    Paterson, I.; Lombart, H.-G.; Allerton, C. Org. Lett. 1999, 1, 19-22. Link to Publication
  130. Studies towards the synthesis of lophotoxin and pukalide: synthesis of the 14- membered macrocyclic core and some acyclic structural analogues.
    Paterson, I.; Brown, R. E.; Urch, C. Tetrahedron Lett. 1999, 40, 5807-5810. Link to Publication
  131. Synthesis of cytotoxic marine macrolides: an aldol-based approach to spongistatin 1 (altohyrtin A).
    Paterson, I.; Gibson, K. R.; Keown, L. E.; Norcross, R. D.; Oballa, R. M.; Wallace, D. J. Current Trends in Organic Synthesis, Scolastico, C., Nicotra, F., Eds., pp 299-306, Plenum, New York, 1999.
  132. Total synthesis of the antimicrotubule agent (+)-discodermolide using boron-mediated aldol reactions of chiral ketones.
    Paterson, I.; Florence, G. J.; Gerlach, K.; Scott, J. P. Angew. Chem. Int. Ed. 2000, 39, 377-380. Angew. Chem. 2000, 112, 385-388. Link to Publication
  133. Stereocontrolled aldol reactions in the total synthesis of polyketide natural products.
    Paterson, I.; Cowden, C. J.; Wallace, D. J. Modern Carbonyl Chemistry, Otera, J., Ed., pp 249-297, Wiley-VCH, Weinheim, 2000.
  134. Total synthesis of (+)-concanamycin F.
    Paterson, I.; Doughty, V. A.; McLeod, M. D.; Trieselmann, T. Angew. Chem. Int. Ed. 2000, 39, 1308-1317. Angew. Chem. 2000, 112, 1364-1368. Link to Publication
  135. Studies in marine polypropionate synthesis: total synthesis of (-)-baconipyrone C.
    Paterson, I.; Chen, D. Y.-K.; Acena, J. L.; Franklin, A. F. Org. Lett. 2000, 2, 1513- 1516. Link to Publication
  136. A combinatorial approach to polyketide-type libraries via iterative asymmetric aldol reactions performed on solid support.
    Paterson, I.; Donghi, M.; Gerlach, K. Angew. Chem. Int. Ed. 2000, 39, 3315-3319. Angew. Chem. 2000, 112, 3453-3457. Link to Publication
  137. Synthesis of (+)-discodermolide and analogues by control of asymmetric induction in aldol reactions of γ-chiral (Z)-enals.
    Paterson, I.; Florence, G. J. Tetrahedron Lett. 2000, 41, 6935-6939. Link to Publication
  138. Asymmetric aldol reactions using boron enolates: applications to polyketide synthesis.
    Paterson, I.; Doughty, V. A.; Florence, G. J.; Gerlach, K.; McLeod, M. D.; Scott, J. P.; Trieselmann, T. ACS Symposium Series 783, Organoboranes for Syntheses, Ramachandran, P. V., Brown, H. C. Ed., Ch 14, pp 195-206, American Chemical Society, Washington, DC, 2000.
  139. Synthesis of the macrocyclic core of laulimalide.
    Paterson, I.; De Savi, C.; Tudge, M. Org. Lett. 2001, 3, 213-216. Link to Publication
  140. Remote 1,5-stereoinduction in boron aldol reactions of methyl ketones: application to the convergent assembly of the 1,3-polyol sequence of (+)-roxaticin.
    Paterson, I.; Collett, L. A. Tetrahedron Lett. 2001, 42, 1187-1191. Link to Publication
  141. Total synthesis of the callipeltoside aglycon.
    Paterson, I.; Davies, R. D. M.; Marquez, R. Angew. Chem. Int. Ed. 2001, 40, 603- 607. Angew. Chem. 2001, 113, 623-627. Link to Publication
  142. A practical synthesis of (+)-discodermolide and analogues: fragment union by complex aldol reactions.
    Paterson, I.; Florence, G. J.; Gerlach, K.; Scott, J. P.; Sereinig, N. J. Am. Chem. Soc. 2001, 123, 9535-9544. Link to Publication
  143. Total synthesis of the microtubule-stabilizing agent (-)-laulimalide.
    Paterson, I.; De Savi, C.; Tudge, M. Org. Lett. 2001, 3, 3149-3152. Link to Publication
  144. Stereocontrolled total synthesis of (+)-altohyrtin A/spongistatin 1.
    Paterson, I.; Chen, D. Y.-K.; Coster, M. J.; Acena, J. L.; Bach, J.; Gibson, K. R.; Keown, L. E.; Oballa, R. M.; Trieselmann, T.; Wallace, D. J.; Hodgson, A.; Norcross, R. D. Angew. Chem. Int. Ed. 2001, 40, 4055-4060. Angew. Chem. 2001, 113, 4179-4184. Link to Publication
  145. Boron-mediated aldol reactions of ethyl ά-(N,N)-dibenzylamino ketones: control of enolisation geometry and π-facial selectivity.
    Paterson, I.; Mackay, A. C. Tetrahedron Lett. 2001, 42, 9269-9272. Link to Publication
  146. Total synthesis of siphonarin B and dihydrosiphonarin B.
    Paterson, I.; Chen, D. Y. K.; Franklin, A. S. Org. Lett. 2002, 4, 391-394. Link to Publication
  147. Total synthesis of altohyrtin A (spongistatin 1): an alternative synthesis of the CD-spiroacetal subunit.
    Paterson, I.; Coster, M. J. Tetrahedron Lett. 2002, 43, 3285-3289. Link to Publication
  148. Towards the combinatorial synthesis of polyketide libraries: Asymmetric aldol reactions with alpha-chiral aldehydes on solid support.
    Paterson, I.; Temal-Laib, T. Org. Lett. 2002, 4, 2473-2476. Link to Publication
  149. Studies in marine macrolide synthesis: stereocontrolled synthesis of a C21-C34 subunit of the aplyronines.
    Paterson, I.; Blakey, S. B.; Cowden, C. J. Tetrahedron Lett. 2002, 43, 6005-6008. Link to Publication
  150. Actin-binding marine macrolides: Total synthesis and biological importance.
    Yeung, K. S.; Paterson, I. Angew. Chem. Int. Ed. 2002, 41, 4632-4653. Link to Publication
  151. 1,6-asymmetric induction in boron-mediated aldol reactions: Application to a practical total synthesis of (+)-discodermolide.
    Paterson, I.; Delgado, O.; Florence, G. J.; Lyothier, I.; Scott, J. P.; Sereinig, N. Org. Lett. 2003, 5, 35-38. Link to Publication
  152. Stereocontrolled total synthesis of (+)-leucascandrolide A.
    Paterson, I.; Tudge, M. Angew. Chem. Int. Ed. 2003, 42, 343-348. Link to Publication
  153. A highly enantioselective catalyst for the asymmetric Nozaki-Hiyama-Kishi reaction of allylic and vinylic halides.
    Berkessel, A.; Menche, D.; Sklorz, C. A.; Schroeder, M.; Paterson, I. Angew. Chem. Int. Ed. 2003, 42, 1032-1035. Link to Publication
  154. Toward the synthesis of peloruside A: Fragment synthesis and coupling studies.
    Paterson, I.; Di Francesco, M. E.; Kuhn, T. Org. Lett. 2003, 5, 599-602. Link to Publication
  155. Synthesis and biological evaluation of spongistatin/altohyrtin analogues: E-ring dehydration and C46 side-chain truncation.
    Paterson, I.; Acena, J. L.; Bach, J.; Chen, D. Y. K.; Coster, M. J. J. Chem. Soc., Chem. Commun. 2003, 4, 462-463. Link to Publication
  156. Discodermolide interferes with the binding of tau protein to microtubules.
    Kar, S.; Florence, G. J.; Paterson, I.; Amos, L. A. FEBS. Lett. 2003, 539, 34-36. Link to Publication
  157. Toward the total synthesis of phorboxazole A: synthesis of an advanced C4-C32 subunit using the Jacobsen hetero Diels-Alder reaction.
    Paterson, I.; Luckhurst, C. A. Tetrahedron Lett. 2003, 44, 3749-3754. Link to Publication
  158. Toward the synthesis of reidispongiolide A: Stereocontrolled synthesis of the C17-C22 and C23-C35 degradation fragments.
    Paterson, I.; Ashton, K.; Britton, R.; Knust, H. Org. Lett. 2003, 5, 1963-1966. Link to Publication
  159. A fully stereocontrolled total synthesis of (+)-leucascandrolide A.
    Paterson, I.; Tudge, M. Tetrahedron. 2003, 59, 6833-6849. Link to Publication
  160. The development of a practical total synthesis of discodermolide, a promising microtubule-stabilizing anticancer agent.
    Paterson, I.; Florence, G. J. Eur. J. Org. Chem. 2003, 12, 2193-2208. Link to Publication
  161. Stereocontrolled total synthesis of (-)-callipeltoside A.
    Paterson, I.; Davies, R. D. M.; Heimann, A. C.; Marquez, R.; Meyer, A. Org. Lett. 2003, 23, 4477-4480. Link to Publication
  162. Synthesis of novel discodermolide analogues with modified hydrogen-bonding donor/acceptor sites.
    Paterson, I.; Delgado, O. Tetrahedron Lett. 2003, 44, 8877-8882. Link to Publication
  163. Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 4: Preparation of fragment C7-24.
    Mickel, S. J.; Paterson, I.; Florence, G. et al. Org. Process Res. Dev. 2004, 8, 113-121. Link to Publication
  164. Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 5: Linkage of fragments C1-6 and C7-24 and Finale.
    Mickel, S. J.; Paterson, I.; Florence, G.; Lyothier, I. et al. Org. Process Res. Dev. 2004, 8, 122-130. Link to Publication
  165. Synthesis of novel 11-desmethyl analogues of laulimalide by Nozaki-Kishi coupling.
    Paterson, I.; Bergmann, H.; Menche, D.; Berkessel, A. Org. Lett. 2004, 6, 1293-1295. Link to Publication
  166. Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae.
    Paterson, I.; Britton, R.; Delgado, O.; Wright, A. E. Chem. Commun. 2004, 6, 632-633. Link to Publication
  167. A quantitative evaluation of the effects of inhibitors of tubulin assembly on polymerization induced by discodermolide, epothilone B, and paclitaxel.
    Dabydeen, D. A.; Paterson, I.; Florence, G. J.; Hamel, E. Cancer Chemotherapy and Pharmacology. 2004, 53, 397-403. Link to Publication
  168. Studies towards the synthesis of superstolide A: An aldol-based construction of an advanced C1-C5/C20-C26 segment.
    Paterson, I.; Mackay, A. Synlett. 2004, 8, 1359-1362. Link to Publication
  169. Synthesis of antimicrofilament marine macrolides: Synthesis and configurational assignment of a C5-C16 degradation fragment of reidispongiolide A.
    Paterson, I.; Britton, R.; Ashton, K.; Knust, H.; Stafford, J. PNAS. 2004, 101, 11986-11991. Link to Publication
  170. Total synthesis and configurational assignment of (-)-dictyostatin, a microtubule-stabilizing macrolide of marine sponge origin.
    Paterson, I.; Britton, R.; Delgado, O.; Meyer, A.; Poullennec, K. G. Angew. Chem. Int. Ed. 2004, 43, 4629-4633. (Cover picture: Angew. Chem. Int. Ed. 2004, 43, 4537.) Link to Publication
  171. Phorboxazole B synthetic studies: construction of C(1-32) and C(33-46) subtargets.
    Paterson, I.; Steven, A.; Luckhurst, C. A. Org. Biomol. Chem. 2004, 2, 3026-3038. Link to Publication
  172. Total Synthesis of (+)-discodermolide: An Improved Endgame Exploiting a Still-Gennari Type Olefination with a C1-C8 Β-ketophosponate fragment.
    Paterson, I.; Lyothier, I. Org. Lett. 2004, 6(26), 4933-4936. Link to Publication
  173. A second generation Total Synthesis of (+)-Discodermolide: The Development of a Practical Route using Solely Substrate-Based Stereocontrol.
    Paterson, I.; Delgado, O.; Florence, G. J.; Lyothier, I.; O'Brien, M.; Scott, J. P.; Sereinig, N. J. Org. Chem. 2005, 70 (1), 150-160. Link to Publication
  174. Stereocontrolled Total Synthesis of (-)-Aurisides A and B.
    Paterson, I.; Florence, G. J; Heimann, A. C; Mackay, A. C. Angew. Chem. Int. Ed. 2005, 1130-1133. Link to Publication
  175. Design, synthesis and biological evaluation of novel, simplified analogues of laulimalide: modification of the side chain.
    Paterson, I.; Menche, D.; Hakansson A. E.; Longstaff, A.; Wong, D.; Barasoain, I.; Buey, R. M.; Diaz, J. F. Bioorg. Med. Chem. Lett. 2005, 15 (9), 2243-2247. Link to Publication
  176. Conformational studies and solution structure of laulimalide and simplified analogues using NMR spectroscopy and molecular modelling.
    Paterson, I.; Menche, D.; Britton, R.; Hakansson, A. E.; Silva-Martinez, M. A. Tetrahedron Lett. 2005, 46 (21), 3677-3682. Link to Publication
  177. The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the AB-spiroacetal segment.
    Paterson, I.; Coster, M. J.; Chen, D. Y.; Oballa, R. M.; Wallace, D. J.; Norcross, R. D. Org. Biomol. Chem. 2005, 3 (13), 2399-2409. Link to Publication
  178. The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the CD-spiroacetal segment.
    Paterson, I.; Coster, M. J.; Chen, D. Y.; Gibson, K. R.; Wallace, D. J. Org. Biomol. Chem. 2005, 3 (13), 2410-2419. Link to Publication
  179. The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the southern hemisphere EF segment.
    Paterson, I.; Coster, M. J.; Chen, D. Y.; Acena, J. L.; Bach, J.; Keown, L. E.; Trieselmann, T. Org. Biomol. Chem. 2005, 3 (13), 2420-2430. Link to Publication
  180. The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: fragment couplings, completion of the synthesis, analogue generation and biological evaluation.
    Paterson, I.; Chen, D. Y.; Coster, M. J.; Acena, J. L.; Bach, J.; Wallace, D. J. Org. Biomol. Chem. 2005, 3 (13), 2431-2440. Link to Publication
  181. Development of a third-generation total synthesis of (+)-discodermolide: an expedient Still-Gennari-type fragment coupling utilizing an advanced beta-ketophosphonate.
    Paterson, I.; Lyothier, I. J. Org. Chem. 2005, 70 (14), 5494-5507. Link to Publication
  182. Towards the combinatorial synthesis of spongistatin fragment libraries by using asymmetric aldol reactions on solid support.
    Paterson, I.; Gottschling, D.; Menche, D. Chem. Commun. (Camb). 2005, 28, 3568-3570. Link to Publication
  183. Toward the synthesis of spirastrellolide A: Construction of a tetracyclic C26-C40 subunit containing the DEF-bis-spiroacetal.
    Paterson, I.; Anderson, E. A.; Dalby, S. M.; Loiseleur, O. Org. Lett. 2005, 19, 4121-4124. Link to Publication
  184. Toward the synthesis of spirastrellolide A: Construction of two C1-C25 diastereomers containing the BC-spiroacetal.
    Paterson, I.; Anderson, E. A.; Dalby, S. M.; Loiseleur, O. Org. Lett. 2005, 19, 4125-4128. Link to Publication
  185. The renaissance of natural products as drug candidates.
    Paterson, I.; Anderson, E. A. Science 2005, 5747, 451-453. Link to Publication
  186. Synthesis of the C1-C21 southern hemisphere of the originally proposed structure of spirastrellolide A.
    Paterson, I.; Anderson, E. A.; Dalby, S. M. Synthesis 2005, 3225-3228. Link to Publication
  187. Advances in the total synthesis of biologically important marine macrolides.
    Yeung, K.-S.; Paterson, I. Chem. Rev. 2005, 105 (12), 4237-4313. Link to Publication
  188. Microtubule interactions with chemically diverse stabilizing agents: Thermodynamics of binding to the paclitaxel site predicts cytotoxicity.
    Buey, R. M.; Barasoain, I.; Jackson, E.; Meyer, A.; Giannakakou. P.; Paterson, I.; Moobery, S.; Andreu, J. M,; Diaz, J. F. Chemistry & Biology 2005, 12 (12), 1269-1279. Link to Publication
  189. Total Synthesis and Stereochemical Reassignment of (+)-Dolastatin 19.
    Paterson, I.; Findlay, A. D.; Florence, G. J. Org. Lett. 2006, 8, 2131-2134. Link to Publication
  190. Synthesis of the DEF-bis-spiroacetal of spirastrellolide A exploiting a double asymmetric dihydroxylation/spiroacetalisation strategy.
    Paterson, I.; Anderson, E. A.; Dalby, S. M.; Lim, J. H.; Maltas, P.; Moessner, C. Chem. Commun. 2006, 4186-4188. Link to Publication
  191. The Tubulin-Bound Conformation of Discodermolide Derived by NMR Studies in Solution Supports a Common Pharmacophore Model for Epothilone and Discodermolide.
    Sanchez-Pedregal, V. M.; Kubicek, K.; Meiler, J.; Lyothier, I. Paterson, I.; Carlomagno, T. Angew. Chem. Int. Ed. 2006, 44, 7388-7394. Link to Publication
  192. Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid.
    Paterson, I.; Gardner, N. Chem. Commun. 2007, 1, 47-49. Link to Publication
  193. Total synthesis of polyketides using asymmetric aldol reactions.
    Paterson, I. Asymmetric Synthesis [Wiley-VCH Verlag GmbH&Co.], 2007, 278-282.
  194. Synthesis and biological evaluation of novel analogues of dictyostatin.
    Paterson, I.; Gardner, N. M.; Poullennec, K. G.; Wright, A. E. Bioorg. Med. Chem. Lett. 2007, 2443-2447. Link to Publication
  195. Synthesis of two diastereomeric C1-C22 fragments of spirastrellolide A.
    Paterson, I.; Anderson, E. A.; Dalby, S. M.; Genovino, J.; Lim, J. H.; Moessner, C. Chem Commun. 2007, 1852-1854. Link to Publication
  196. Total synthesis and stereochemical reassignment of (+)-dolastatin 19, a cytotoxic marine macrolide isolated from Dolabella auricularia.
    Paterson, I.; Findlay, A. D.; Florence, G. J. Tetrahedron 2007, 5806-5819. Link to Publication
  197. Progress toward a total synthesis of spirastrellolide A.
    Paterson, I.; Anderson, E. A.; Dalby, S. M.; Lim, J. H.; Loiseleur, O.; Maltas, P.; Moessner, C. Pure Appl. Chem. 2007, 79, 467-823. Link to Publication
  198. Total Synthesis of (-)-Reidispongiolide A, an Actin-Targeting Marine Macrolide.
    Paterson, I.; Ashton, K.; Britton, R.; Cecere, G.; Chouraqui, G.; Florence, G. J.; Stafford, J. Angew. Chem. Int. Ed. 2007, 32, 6167-6171. Link to Publication
  199. Synthesis of an Advanced C10-C32 Spiroacetal Fragment and Assignment of the Absolute Configuration of Spirangien A.
    Paterson, I.; Findlay, A. D.; Anderson, E. A. Angew. Chem. Int. Ed. 2007, 35, 6699-6702.Link to Publication
  200. Total Synthesis of (-)-Reidispongiolide A, an Actin-Targeting Macrolide Isolated from the Marine Sponge Reidispongia coerulea.
    Paterson, I.; Ashton, K.; Britton, R.; Cecere, G.; Chouraqui, G.; Florence, G. J.; Knust, H.; Stafford, J. Chemistry - An Asian Journal, 2008, 367-387. Link to Publication
  201. Total synthesis of pteridic acids A and B.
    Paterson, I.; Anderson, E. A.; Findlay, A. D.; Knappy, C. S. Tetrahedron 2008, 64, 4768-4777. Link to Publication
  202. Total Synthesis of Spirastrellolide A Methyl Ester - Part 1: Synthesis of an Advanced C17-C40 Bis-spiroacetal Subunit.
    Paterson, I.; Anderson, E. A,; Dalby, S. M; Lim, J. H.; Genovino, J.; Maltas, P.; Moessner, C. Angew. Chem. Int. Ed. 2008, 3016-3020. Link to Publication
  203. Total Synthesis of Spirastrellolide A Methyl Ester - Part 2: Subunit Union and Completion of the Synthesis.
    Paterson, I.; Anderson, E. A,; Dalby, S. M; Lim, J. H.; Genovino, J.; Maltas, P.; Moessner, C. Angew. Chem. Int. Ed. 2008, 3021-3025. Link to Publication
  204. Development of practical syntheses of the marine anticancer agents discodermolide and dictyostatin.
    Florence, G. J.; Gardner, N. M.; Paterson, I. Nat. Prod. Rep. 2008, 25, 342-375.Link to Publication
  205. Synthetic Mimetics of Actin-Binding Macrolides: Rational Design of Actin-Targeted Drugs.
    Perrins, R. D.; Cecere, G.; Paterson, I.; Marriot, G. Chemistry & Biology 2008, 15, 3, 287-294. Link to Publication
  206. Synthesis and biological evaluation of 10,11-dihydrodictyostatin, a potent analogue of the marine anticancer agent dictyostatin.
    Paterson, I.; Gardner, N. M.; Poullennec, K. G.; Wright, A. E. J. Nat. Prod. 2008, 71, 3, 364-369. Link to Publication
  207. Total Synthesis of (-)-Saliniketals A and B.
    Paterson, I.; Razzak, M.; Anderson, E. A. Org. Lett. 2008, 10(15), 3295-3298. Link to Publication
  208. Total synthesis of cytotoxic marine macrolides: Callipeltoside A, aurisides A and B, and dolastatin 19.
    Paterson, I.; Findlay, A. D. Pure Appl. Chem. 2008, 80, 8, 1773-1782. Link to Publication
  209. The Bound Conformation of Microtubule-Stabilizing Agents: NMR Insights into the Bioactive 3D Structure of Discodermolide and Dictyostatin.
    Canales, A.; Matesanz, R.; Gardner, N. M.; Andreu, J. M.; Paterson, I.; Diaz, J. F.; Jimenez-Barbero, J. Chem. Eur. J. 2008, 14, 25, 7557-7569. Link to Publication
  210. Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide.
    Paterson, I.; Naylor, G. J.; Wright, A. E. Chem. Commun. 2008, 4628-4630. Link to Publication
  211. Total synthesis of the marine macrolide (+)-neopeltolide.
    Paterson, I.; Miller, N. A. Chem. Commun. 2008, 37, 4708-4710. Link to Publication
  212. Total synthesis of (-)-spirangien A and its methyl ester.
    Paterson, I.; Findlay, A. D.; Noti, C. Chem. Commun. 2008, 4, 6408-6410. Link to Publication
  213. Total synthesis and biological evaluation of potent analogues of dictyostatin: Modification of the C2-C6 dienoate region.
    Paterson, I.; Gardner, N. M.; Guzman, E.; Wright, A. E. Bioorg. Med. Chem. Lett. 2008, 18, 6268-6272. Link to Publication
  214. Toward the Total Synthesis of the Brasilinolides: Stereocontrolled Assembly of a C1-C19 Polyol Segment.
    Paterson, I.; Mühlthau, F. A.; Cordier, C. J.; Housden, M. P.; Burton P. M.; Loiseleur, O. Org. Lett. 2009, 11, 353-356. Link to Publication
  215. Toward the Total Synthesis of the Brasilinolides: Construction of a Differentially Protected C20-C38 Segment.
    Paterson, I.; Burton P. M.; Cordier, C. J.; Housden, M. P.; Mühlthau, F. A.; Loiseleur, O. Org. Lett. 2009, 11, 693-696.Link to Publication
  216. Total Synthesis of (-)-Spirangien A, an Antimitotic Polyketide Isolated from the Myxobacterium Sorangium Cellulosum.
    Paterson, I.; Findlay, A. D.; Noti, C. Chem. Asian J. 2009, 594-611. Link to Publication
  217. The Chemical Synthesis of Discodermolide
    Paterson, I.; Florence, G. J. Top. Curr. Chem. 2009, 286, 73. Link to Publication
  218. Total synthesis of novel dictyostatin analogs and hybrids as microtubule-stabilizing anticancer agents.
    Paterson, I.; Gardner, N. M.; Naylor, G. N. Pure Appl. Chem. 2009, 169-180. Link to Publication
  219. Total synthesis and biological evaluation of novel C2-C6 region analogues of dictyostatin.
    Paterson, I.; Gardner, N. M.; Guzman, E.; Wright, A. E. Bioorg Med. Chem. 2009, 2282-2289. Link to Publication
  220. Synthesis and stereochemical determination of the spirastrellolides.
    Paterson, I.; Dalby, S. M. Nat. Prod. Rep. 2009, 26, 865-873. Link to Publication
  221. Recent Advances in the Total Synthesis of Polyketide Natural Products as Promising Anticancer Agents.
    Paterson, I.; Findlay, A. F. Australian J. Chem. 2009, 62, 624-638. Link to Publication
  222. Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin.
    Paterson, I.; Naylor, G. J.; Fujita, T.; Guzman, E.; Wright, A. E. Chem. Commun. 2010, 46, 261-263. Link to Publication
  223. Synthetic Studies towards Iriomoteolide 1a: Stereocontrolled Construction of C1-C9 and C11-C23 Segments Using Lactate Aldol Chemistry
    Paterson, I.; Rubenbauer, P. Synlett. 2010, 4, 571-574. Link to Publication
  224. Total Synthesis and Configurational Validation of (+)-Phorbaside A
    Paterson, I.; Paquet, T. Org. Lett. 2010, 12, 2158-2161. Link to Publication
  225. Total synthesis of (-)-dictyostatin, a microtubule-stabilising anticancer macrolide of marine sponge origin
    Paterson, I.; Britton, R.; Delgado, O.; Gardner, N. M.; Meyer, A.; Naylor, G. J.; Poullennec, K. J. Tetrahedron 2010, 66, 6534-6545. Link to Publication
  226. Molecular Recognition of Peloruside A by Microtubules. The C24 Primary Alcohol is Essential for Biological Activity
    Pera, B.; Razzak, M.; Trigili, C.; Pineda, O.; Canales, A.; Buey, R.; Jiménez-Barbero, J.; Northcote, P. T.; Paterson, I.; Barasoain, I.; Díaz, J. F. ChemBioChem 2010, 11, 1669-1678. Link to Publication
  227. Synthesis of polyketide natural products and analogs as promising anticancer agents.
    Dalby, S. M.; Paterson, I. Curr. Opin. Drug Discov. Devel. 2010, 13, 777-794.
  228. Synthesis of the C1-C13 Tetraenoate Subunit of the Chivosazoles
    Paterson, I.; Kan, S. B. J.; Gibson, L. J. Org. Lett. 2010, 12, 3724-3727. Link to Publication
  229. The stereochemical assignment of acyclic polyols: a computational study of the NMR data of a library of stereopentad sequences from polyketide natural products
    Smith, S. G.; Channon, J. A.; Paterson, I.; Goodman, J. M. Tetrahedron 2010, 66, 6437-6444. Link to Publication
  230. Synthesis of the C15-C35 Northern Hemisphere Subunit of the Chivosazoles
    Paterson, I.; Gibson, L. J.; Kan, S. B. J. Org. Lett. 2010, 12, 5530-5533. Link to Publication
  231. Total Synthesis and Biological Evaluation of a Series of Macrocyclic Hybrids and Analogues of the Antimitotic Natural Products Dictyostatin, Discodermolide, and Taxol
    Paterson, I.; Naylor, G. J.; Gardner, N. M.; Guzman, E.; Wright, A. E. Chem. Asian J. 2011, 6, 459-473. Link to Publication
  232. Leiodermatolide, a Potent Antimitotic Macrolide from the Marine Sponge Leiodermatium sp.
    Paterson, I.; Dalby, S. M.; Roberts, J. C.; Naylor, G. J.; Guzman, E. A.; Isbrucker, R.; Pitts, T. P.; Linley, P.; Dilianska, D.; Reed, J. K.; Wright, A. E. Angew. Chem. Int. Ed. 2011, 50, 1-6. Link to Publication
  233. Structure-Activity Studies of the Pelorusides: New Congeners and Semi-Synthetic Analogues
    Singh, A. J.; Razzak, M.; Teesdale-Spittle, P.; Gaitanos, T. N.; Wilmes, A.; Paterson, I.; Goodman, J. M.; Miller, J. H.; Northcote, P. T. Org. Biomol. Chem. 2011, 9, 4456-4466. Link to Publication
  234. Insights into the Interaction of Discodermolide and Docetaxel with Tubulin. Mapping the Binding Sites of Microtubule-Stabilizing Agents by Using an Integrated NMR and Computational Approach
    Canales, A.; Rodríguez-Salarichs, J.; Trigili, C.; Nieto, L.; Coderch, C.; Andreu, J. M., Paterson, I.; Jiménez-Barbero, J.; Díaz, J. F. ACS Chem. Biol. 2011, 6, 789-799. Link to Publication
  235. Strategy evolution in the total synthesis of spirastrellolide A methyl ester
    Paterson, I.; Dalby, S. M.; Maltas, P. Isr. J. Chem. 2011, 51, 406-419. Link to Publication
  236. Synthesis of the Macrocyclic Core of Leiodermatolide
    Paterson, I.; Paquet, T.; Dalby, S. M. Org. Lett. 2011, 13, 4398-4401. Link to Publication
  237. Stereocontrolled total synthesis of (+)-concanamycin F: the strategic use of boron-mediated aldol reactions of chiral ketones
    Paterson, I.; Steadman neé Doughty, V. A.; McLeod, M. D.; Trieselmann, T. Tetrahedron 2011, 67, 10119-10128. Link to Publication
  238. Synergistic interactions between peloruside A and other microtubule-stabilizing and destabilizing agents in cultured human ovarian carcinoma cells and murine T cells
    Wilmes, A.; O'Sullivan, D.; Chan, A.; Chandrahasen, C.; Paterson, I.; Northcote, P. T.; La Flamme, A. C.; Miller, J. H. Cancer Chemoth Pharm 2011, 117-126. Link to Publication
  239. Total synthesis of Alotaketal A
    Xuan, M.; Paterson, I.; Dalby, S. M. Org. Lett. 2012, 14, 5492-5495. Link to Publication
  240. The stereocontrolled total synthesis of spirastrellolide A methyl ester. Expedient construction of the key fragments
    Paterson I, Anderson EA, Dalby SM, Lim JH, Maltas P, Loiseleur O, Genovino J, Moessner C Org. Biomol. Chem. 2012, 10, 5861-5872. Link to Publication
  241. The stereocontrolled total synthesis of spirastrellolide A methyl ester. Fragment coupling studies and completion of the synthesis
    Paterson, I.; Anderson, E.A.; Dalby, S. M.; Lim, J. H.; Maltas, P. Org. Biomol. Chem. 2012, 10, 5873-5886. Link to Publication
  242. A second-generation total synthesis of spirastrellolide A methyl ester
    Paterson, I.; Maltas, P.; Dalby, S. M.; Lim, J. H.; Anderson, E. A. Angew. Chem. Int. Ed. 2012, 51, 2749-2753. Link to Publication
  243. Total Synthesis of Aplyronine C
    Paterson, I.; Fink, S. J.; Lee, L. Y.; Atkinson, S. J.; Blakey, S. B. Org. Lett. 2013, 15, 3118-3121. Link to Publication
  244. Total synthesis of (+)-Spirastrellolide A Methyl Ester: Challenges and discoveries
    Paterson, I.; Maltas, P.; Anderson, E. A. Pure and Applied Chemistry 2013, 85, 1133-1147. Link to Publication
  245. Total Synthesis of (-)-Rhizopodin
    Dalby, S. M., Goodwin-Tindall, J.; Paterson, I. Angew. Chem. Int. Ed. 2013, 52, 6517-6521. Link to Publication
  246. Synthesis of the C1-C11 western fragment of Madeirolide A
    Paterson, I.; Haslett, G. W. Org. Lett. 2013, 15, 1338-1341. Link to Publication
  247. The Impact of the Mukaiyama Aldol Reaction in Total Synthesis
    Kan, S. B. J.; Ng, K. K.-H.; Paterson, I. Angew. Chem. Int. Ed. 2013, 52, 9097-9108. Link to Publication
  248. Total synthesis of the antimitotic marine macrolide (-)-leiodermatolide
    Paterson, I.; Ng, K. K.-H.; Williams, S.; Millican, D. C.; Dalby, S. M. Angew. Chem. Int. Ed. 2014, 53, 2692-2695. Link to Publication
  249. Molecular Recognition of Epothilones by Microtubules and Tubulin Dimers Revealed by Biochemical and NMR Approaches
    Canales, A.; Nieto, L.; Rodríguez-Salarichs, J.; Sánchez-Murcia, P. A.; Coderch, C.; Cortés-Cabrera, A.; Paterson, I.; Carlomagno, T.; Gago, F.; Andreu, J. M.; Altmann, K. H.; Jiménez-Barbero, J.; Díaz, J. F.ACS Chem. Biol. 2014, 9, 1033-1043. Link to Publication
  250. Total Synthesis of Jiadifenolide
    Paterson, I.; Xuan, M.; Dalby, S. M. Angew. Chem. Int. Ed. ASAP, . Link to Publication
  251. Structural and Biochemical Studies of Actin in Complex with Synthetic Macrolide Tail Analogues
    Pereira, J. H.; Petchprayoon, C.; Hoepker, A. C.; Moriarty, N. W.; Fink, S. J.; Cecere, G.; Paterson, I.; Adams, P. D.; Marriot, G. ChemMedChem 2014, 9, 2286-2293. Link to Publication
  252. Synthetic studies toward the brasilinolides: controlled assembly of a protected C1-C38 polyol based on fragment union by complex aldol reactions
    Paterson, I.; Housden, M. P.; Cordier, C. J.; Burton, P. M.; Mühlthau, F. A.; Loiseleur, O. Org. Biomol. Chem. 2015, 13, 5716-5733. Link to Publication

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