Publications

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  1. Homosolvolysis.
    Low, H.; Paterson, I.; Tedder, J. M.; Walton, J. C. J. Chem. Soc., Chem. Commun. 1977, 171-172. Link to Publication
  2. t-Butylation of aldehydes and ketones by the Friedel-Crafts alkylation of trimethylsilyl enol ethers.
    Chan, T. H.; Paterson, I.; Pinsonnault, J. Tetrahedron Lett. 1977, 4183-4186.
  3. Free radical addition to olefins. Part 23. Kinetics of the addition of chloroiodomethane to ethylene and vinyl fluoride.
    Paterson, I.; Tedder, J. M.; Walton, J. C. J. Chem. Soc., Perkin Trans. II 1978, 884- 887. Link to Publication
  4. Methylenation of lactones and esters: zinc bromide catalysed phenylthiomethylation of O-silylated enolates.
    Paterson, I.; Fleming, I. Tetrahedron Lett. 1979, 993-994. Link to Publication
  5. Regiospecific α-methylenation and α-methylation of ketones: titanium tetrachloride- promoted phenylthiomethylation of silyl enol ethers.
    Paterson, I.; Fleming, I. Tetrahedron Lett. 1979, 995-998. Link to Publication
  6. α-Alkylation of ketones, esters, and lactones: zinc bromide catalysed alkylation of O-silylated enolates, a synthesis of (±)-ar-turmerone.
    Paterson, I. Tetrahedron Lett. 1979, 1519-1520.
  7. α-Alkylation and α-alkylidenation of carbonyl compounds: Lewis acid-promoted phenylthioalkylation of O-silylated enolates.
    Paterson, I.; Fleming, I. Tetrahedron Lett. 1979, 2179-2182.
  8. Allylsilanes in organic synthesis: a method for the introduction of two carbon substituents in place of carbonyl oxygen.
    Fleming, I.; Paterson, I. Synthesis1979, 446-448.
  9. γ-Sulphenylation of β-unsaturated aldehydes, ketones, and esters: the use of O -silylated dienolates.
    Fleming, I.; Goldhill, J.; Paterson, I. Tetrahedron Lett. 1979, 3205-3208.
  10. γ-Alkylation of unsaturated ketones and esters: zinc bromide catalysed alkylation of O-silylated dienolates.
    Fleming, I.; Goldhill, J.; Paterson, I. Tetrahedron Lett. 1979, 3209-3212.
  11. A simple synthesis of carvone using silyl enol ethers.
    Fleming, I.; Paterson, I. Synthesis 1979, 736-738.
  12. The formation of allyl sulphides by phenylthio-migration: control by silicon.
    Fleming, I.; Paterson, I.; Pearce, A. J. Chem. Soc., Perkin Trans. I 1981, 256-262. Link to Publication
  13. O-Silylated enolates in organic synthesis: α-alkylation of carbonyl compounds by 1,3-dithienium fluoroborate.
    Paterson, I.; Price, L. G. Tetrahedron Lett. 1981, 22, 2829-2832.
  14. O-Silylated dienolates in organic synthesis: γ-selective alkylation of unsaturated carbonyl compounds by 1,3-dithienium fluoroborate.
    Paterson, I.; Price, L. G. Tetrahedron Lett. 1981, 22, 2833-2836.
  15. O-Silylated enolate phenylthioalkylation: a new synthesis of unsaturated 1,5- dicarbonyl compounds.
    Khan, H. A.; Paterson, I. Tetrahedron Lett. 1982, 23, 2399-2402.
  16. O-Silylated enolate phenylthioalkylation: a synthesis of α,β-unsaturated 5- and 6- membered lactones.
    Khan, H. A.; Paterson, I. Tetrahedron Lett. 1982, 23, 5083-5086.
  17. A stereoselective synthesis of the chiral sequence of erythronolide A.
    Stork, G.; Paterson, I.; Lee, F. K. C. J. Am. Chem. Soc. 1982, 104, 4686-4688.Link to Publication
  18. O-Silylated enolates in organic synthesis: sulphur-mediated alkylation of esters with alkenes.
    Patel, S. K.; Paterson, I. Tetrahedron Lett. 1982, 24, 1315-1318.
  19. Studies in macrolide synthesis: a synthesis of two chiral fragments of oleandomycin and lankamycin.
    Paterson, I. Tetrahedron Lett. 1983,24, 1311-1314.
  20. Studies in macrolide synthesis; an efficient synthesis of two chiral fragments of erythronolide A.
    Paterson, I.; Patel, S. K.; Porter, J. R. Tetrahedron Lett. 1983, 24, 3395-3396.
  21. Alkene carbosulphenylation and carboselenylation: the use of allyltrimethylsilane and O-silylated enolates.
    Alexander, R. P.; Paterson, I. Tetrahedron Lett. 1983, 24, 5911-5914.
  22. Preparation of tritium-labelled meta-aminolevamisole of high specific radioactivity by catalytic dehalogenation.
    Lewis, J. A.; Paterson, I. J. Labelled Compounds and Radiopharmaceuticals 1984, 21, 945-959.
  23. Recent developments in the total synthesis of macrolide antibiotics.
    Paterson, I.; Mansuri, M. M. Tetrahedron 1985, 41, 3569-3624.
  24. Asymmetric alkylation and sulphenylation of chiral O-silylated imide enolates.
    Alexander, R. P.; Paterson, I. Tetrahedron Lett. 1985, 26, 5339-5340.
  25. Enantioselective aldol condensations: the use of ketone boron enolates with chiral ligands attached to boron.
    Paterson, I.; Lister, M. A.; McClure, C. K. Tetrahedron Lett. 1986, 27, 4787-4790.
  26. Studies in macrolide synthesis: aldol condensations of chiral ethyl ketones via boron enolates.
    Paterson, I.; McClure, C. K. Tetrahedron Lett. 1987, 28, 1229-1232.
  27. Studies in polyether synthesis using polyepoxide cyclisations.
    Paterson, I.; Boddy, I.; Mason, I. Tetrahedron Lett. 1987, 28, 5205-5208.
  28. A force field model for boron enolates.
    Goodman, J. M.; Paterson, I.; Kahn, S. D. Tetrahedron Lett. 1987, 28, 5209-5212.
  29. Degradation of oleandomycin: controlled removal of sugars to give oleandolide C3,C5-acetonide.
    Paterson, I.; Arya, P. Tetrahedron 1988, 44, 253-260.
  30. α-Alkylation and α-alkylidenation of carbonyl compounds by O-silylated enolate phenylthioalkylation.
    Paterson, I. Tetrahedron 1988, 44, 4207-4219.
  31. Aldol condensations of chiral ethyl ketones: control by chiral boron reagents.
    Paterson, I.; Lister, M. A. Tetrahedron Lett. 1988, 29, 585-588.
  32. Studies in macrolide synthesis: a concise asymmetric synthesis of a macrolide intermediate for the erythronolides.
    Paterson, I.; Laffan, D. D. P.; Rawson, D. J. Tetrahedron Lett. 1988, 29, 1461-1464.
  33. New asymmetric aldol methodology using boron enolates.
    Paterson, I. Chemistry and Industry (London) 1988, 390-394.
  34. Studies in polyether synthesis: spiroacetal formation by directed bisepoxide cyclisation.
    Paterson, I.; Boddy, I. Tetrahedron Lett. 1988, 29, 5301-5304. Link to Publication
  35. Aldol reactions of methyl ketones using chiral boron reagents: a reversal in aldehyde enantioface selectivity.
    Paterson, I.; Goodman, J. M. Tetrahedron Lett. 1989, 30, 997-1000. Link to Publication
  36. A short asymmetric synthesis of a C19-C27 segment of rifamycin S. Kinetic resolution in the aldol reactions of ethyl ketones using chiral boron reagents.
    Paterson, I.; McClure, C. K.; Schumann, R. C. Tetrahedron Lett. 1989, 30, 1293-1296. Link to Publication
  37. Studies in marine cembranolide synthesis: a synthesis of 2,3,5-trisubstituted furan intermediates for lophotoxin and pukalide.
    Paterson, I.; Gardner, M.; Banks, B. J. Tetrahedron 1989, 45, 5283-5286. Link to Publication
  38. Studies in polyether synthesis: controlled bisepoxide cyclisation using a β-diketone group.
    Paterson, I.; Craw, P. A. Tetrahedron Lett. 1989, 30, 5799-5802.
  39. Aldol reactions in polypropionate synthesis: high π-face selectivity of enol borinates from α-chiral methyl and ethyl ketones under substrate control.
    Paterson, I.; Goodman, J. M; Isaka, M. Tetrahedron Lett. 1989, 30, 7121-7124.
  40. Studies in macrolide synthesis: a highly stereoselective synthesis of (+)-(9S)- dihydroerythronolide A using macrocyclic stereocontrol.
    Paterson, I.; Rawson, D. J. Tetrahedron Lett. 1989, 30, 7463-7466.
  41. Theoretical studies of aldol stereoselectivity: the development of a force field model for enol borinates and the investigation of chiral enolate π-face selectivity.
    Goodman, J. M.; Kahn, S. D.; Paterson, I. J. Org. Chem. 1990, 55, 3295-3303. Link to Publication
  42. Transition state modelling of the aldol reaction of boron enolates: a force field approach.
    Bernardi, A.; Capelli, A. M.; Gennari, C.; Goodman, J. M.; Paterson, I. J. Org. Chem. 1990, 55, 3576-3581. Link to Publication
  43. Stereoselective aldol reactions of β-chlorovinyl ketones using dienol borinates: a new synthesis of dihydropyrones.
    Paterson, I.; Osborne, S. A. Tetrahedron Lett. 1990, 31, 2213-2216. Link to Publication
  44. Enantio- and diastereoselective aldol reactions of achiral ethyl and methyl ketones with aldehydes: the use of enol diisopinocampheylborinates.
    Paterson, I.; Goodman, J. M.; Lister, M. A.; Schumann, R. C.; McClure, C. K.; Norcross, R. D. Tetrahedron 1990, 46, 4663-4684. Link to Publication
  45. Total synthesis of the esterase inhibitor (±)-ebelactone A using an aldol-Claisen strategy.
    Paterson, I.; Hulme, A. N. Tetrahedron Lett. 1990, 31, 7513-7516. Link to Publication
  46. Origins of stereoselectivity in chiral boron enolate aldol reactions: a computational study using transition state modelling.
    Bernardi, A.; Capelli, A. M.; Comotti, A.; Gennari, C.; Gardner, M.; Goodman, J. M.; Paterson, I. Tetrahedron 1991,47, 3471-3484. Link to Publication
  47. Asymmetric aldol reactions using chiral boron reagents: application to the synthesis of tirandamycin A.
    Paterson, I.; Lister, M. A.; Ryan, G. R. Tetrahedron Lett. 1991, 32, 1749-1752. Link to Publication
  48. Enol borinates in organic synthesis: regioselective α-sulphenylation and α-selenenylation of ketones.
    Paterson, I.; Osborne, S. Synlett 1991, 2, 145-146. Link to Publication
  49. The aldol reaction for transition metal enolates.
    Paterson, I. Comprehensive Organic Synthesis: Selectivity for Synthetic Efficiency, Trost, B. M., Ed., Vol. 2, pp 301-319, Pergamon Press, Oxford, 1991.
  50. Stereocontrolled, two-directional, chain synthesis using the boron aldol reaction and double Ireland-Claisen rearrangement.
    Paterson, I.; Hulme, A. N.; Wallace, D. J. Tetrahedron Lett. 1991, 32, 7601-7604. Link to Publication
  51. Studies in polypropionate synthesis: a general approach to the synthesis of stereopentads.
    Paterson, I.; Channon, J. A. Tetrahedron Lett. 1992, 33, 797-800.
  52. Studies in polypropionate synthesis: stereocontrolled synthesis of (-)-denticulatins A and B.
    Paterson, I.; Perkins, M. V. Tetrahedron Lett. 1992, 33, 801-804. Link to Publication
  53. Studies in macrolide synthesis: a stereocontrolled synthesis of a (9S)-macrolide intermediate for oleandomycin using chiral boron reagents.
    Paterson, I.; Lister, M. A.; Norcross, R. D. Tetrahedron Lett. 1992, 33, 1767-1770. Link to Publication
  54. A stereocontrolled synthesis of a C19-C32 / C17-C30 segment for swinholide A and misakinolide A, cytotoxic dimeric macrolides from Theonella swinhoei.
    Paterson, I.; Cumming, J. G. Tetrahedron Lett. 1992, 33, 2847-2850. Link to Publication
  55. Developing a force field for the transition state of the aldol reaction of enolborinates: evaluation of the use of fixed point charges.
    Bernardi, A.; Cassinari, A.; Comotti, A.; Gardner, M.; Gennari, C.; Goodman, J.; Paterson, I. Tetrahedron1992, 48, 4183-4192. Link to Publication
  56. Diastereofacial selectivity in the aldol reactions of chiral α-methyl aldehydes: a computer modelling approach.
    Gennari, C.; Vieth, S.; Comotti, A.; Vulpetti, A.; Goodman, J. M.; Paterson, I. Tetrahedron 1992, 48, 4439-4458. Link to Publication
  57. Stereocontrolled synthesis of a C1-C15 segment for the marine macrolides, swinholide A and scytophycin C: use of a vinylogous Mukaiyama aldol reaction.
    Paterson, I.; Smith, J. D. J. Org. Chem.1992, 57, 3261-3264. Link to Publication
  58. Studies in polypropionate synthesis: high π-face selectivity in syn aldol reactions of Sn(II) enolates from (R)- and (S)-1-(benzyloxy)-2-methylpentan-3-one.
    Paterson, I.; Tillyer, R. D. Tetrahedron Lett. 1992, 33, 4233-4236. Link to Publication
  59. The rational design of highly stereoselective boron enolates using transition-state computer modelling: a novel, asymmetric anti aldol reaction for ketones.
    Gennari, C.; Hewkin, C. T.; Molinari, F.; Bernardi, A.; Comotti, A.; Goodman, J. M.; Paterson, I. J. Org. Chem. 1992, 57, 5173-5177. Link to Publication
  60. New methods and strategies for the stereocontrolled synthesis of polypropionate- derived natural products.
    Paterson, I. Pure Appl. Chem. 1992, 64, 1821-1830.
  61. Meso epoxides in asymmetric synthesis. Enantioselective opening by nucleophiles in the presence of chiral Lewis acids.
    Paterson, I.; Berrisford, D. J. Angew. Chem., Int. Ed. Eng. 1992, 31, 1179-1180. Angew. Chem. 1992, 104, 1204-1205. Link to Publication
  62. Enolisation of ketones by dialkylboron chlorides and triflates: a model for the effect of reagent leaving group, substrate structure and amine base.
    Goodman, J. M.; Paterson, I. Tetrahedron Lett. 1992, 33, 7223-7226. Link to Publication
  63. Origins of π-face selectivity in the aldol reactions of chiral E-enol borinates: a computational study using transition state modelling.
    Vulpetti, A.; Bernardi, A.; Gennari, C.; Goodman, J. M.; Paterson, I. Tetrahedron 1993, 49, 685-696. Link to Publication
  64. Origins of stereoselectivity in the addition of chiral allyl- and crotylboranes to aldehydes: The development and application of a force field model of the transition state.
    Vulpetti, A.; Gardner, M.; Gennari, C.; Bernardi, A.; Goodman, J. M.; Paterson, I. J. Org. Chem. 1993, 58, 1711-1718. Link to Publication
  65. Total synthesis of the marine polypropionate (+)-muamvatin. A configurational model for Siphonariid metabolites.
    Paterson, I; Perkins, M. V. J. Am. Chem. Soc. 1993, 115, 1608-1610. Link to Publication
  66. Studies in biomimetic polyether synthesis: synthesis of an A-ring subunit of etheromycin.
    Paterson, I.; Tillyer, R. D.; Ryan, G. R. Tetrahedron Lett. 1993, 34, 4389-4392. Link to Publication
  67. 1,3-Asymmetric induction in the aldol reactions of α-methylene, β-alkoxy aldehydes.
    Paterson, I.; Bower, S.; Tillyer, R. D. Tetrahedron Lett. 1993, 34, 4393-4396. Link to Publication
  68. High π-face selectivity in anti aldol reactions of E-enol borinates from chiral alkoxymethyl ketones: stereocontrolled synthesis of a C24-C32 polyol subunit of rapamycin.
    Paterson, I.; Tillyer, R. D. J. Org. Chem. 1993, 58, 4182-4184. Link to Publication
  69. Studies in marine macrolide synthesis: a stereocontrolled synthesis of a C17-C32 subunit of scytophycin C.
    Paterson, I.; Yeung, K.-S. Tetrahedron Lett. 1993, 34, 5347-5350. Link to Publication
  70. Studies in marine macrolide synthesis: asymmetric synthesis of C1-C15/C16 subunits of swinholide A and scytophycin C.
    Paterson, I.; Smith, J. D. Tetrahedron Lett. 1993, 34, 5351-5354. Link to Publication
  71. The Horner-Wadsworth-Emmons reaction in natural products synthesis: expedient construction of complex (E)-enones using barium hydroxide.
    Paterson, I.; Yeung, K.-S.; Smaill, J. B. Synlett 1993, 774-776. Link to Publication
  72. Studies in biomimetic polyether synthesis: construction of an ABCD-ring subunit of etheromycin using polyepoxide cascade cyclisations.
    Paterson, I.; Tillyer, R. D.; Smaill, J. B. Tetrahedron Lett. 1993, 34, 7137-7140. Link to Publication
  73. Studies towards the total synthesis of the marine-derived immunosuppressant discodermolide. Asymmetric synthesis of a C1-C8 δ-lactone subunit.
    Paterson, I.; Wren, S. P. J. Chem. Soc., Chem. Commun. 1993, 1790-1793.
  74. Computer-assisted design of chiral boron enolates: the role of ate complexes in determining aldol stereoselectivity.
    Bernardi, A.; Comotti, A.; Gennari, C.; Hewkin, C. T.; Goodman, J. M.; Schlapbach, A.; Paterson, I. Tetrahedron 1994, 50, 1227-1242. Link to Publication
  75. Studies in marine macrolide synthesis: boron and silicon-mediated coupling strategies for swinholide A.
    Paterson, I.; Cumming, J. G.; Smith, J. D.; Ward, R. A. Tetrahedron Lett. 1994, 35, 441-444. Link to Publication
  76. Total synthesis of (-)-preswinholide A.
    Paterson, I.; Smith, J. D.; Ward, R. A.; Cumming, J. G. J. Am. Chem. Soc. 1994, 116, 2615-2616. Link to Publication
  77. Substrate controlled aldol reactions of chiral ethyl ketones: application to the total synthesis of oleandomycin.
    Paterson, I.; Ward, R. A.; Romea, P.; Norcross, R. D. J. Am. Chem. Soc. 1994, 116, 3623-3624. Link to Publication
  78. Towards the synthesis of swinholide A and scytophycin C. A highly stereocontrolled synthesis of (-)-pre-swinholide A.
    Paterson, I.; Cumming, J. G.; Smith, J. D.; Ward, R. A.; Yeung, K.-S. Tetrahedron Lett. 1994, 35, 3405-3408. Link to Publication
  79. Total synthesis of swinholide A and hemiswinholide A.
    Paterson, I.; Yeung, K.-S.; Ward, R. A.; Cumming, J. G.; Smith, J. D. J. Am. Chem. Soc. 1994, 116, 9391-9392. Link to Publication
  80. Recent developments in asymmetric aldol methodology.
    Franklin, A. S.; Paterson, I. Contemp. Org. Synth. 1994, 1, 317-338. Link to Publication
  81. Assignment of the absolute configuration of the siphonarins and baconipyrones. Enantiocontrolled synthesis of a γ-pyrone subunit.
    Paterson, I.; Franklin, A. S. Tetrahedron Lett. 1994, 35, 6925-6928. Link to Publication
  82. A configurational model for siphonariid polypropionates derived from structural and biosynthetic considerations.
    Garson, M. J.; Goodman, J. M.; Paterson, I. Tetrahedron Lett. 1994, 35, 6929-6932.
  83. Studies in polypropionate synthesis: high π-face selectivity in syn and anti aldol reactions of chiral boron enolates of lactate-derived ketones.
    Paterson, I.; Wallace, D. J.; Velazquez, S. M. Tetrahedron Lett. 1994, 35, 9083-9086. Link to Publication
  84. Manipulation of the aldol adducts from lactate-derived ketones. A versatile chiral auxiliary for the asymmetric synthesis of β-hydroxy carbonyl compounds.
    Paterson, I.; Wallace, D. J. Tetrahedron Lett. 1994, 35, 9087-9090. Link to Publication
  85. Studies in macrolide synthesis: Synthesis of oleandolide using substrate- and reagent-controlled aldol reactions of (S)-1-(benzyloxy)-2-methylpentan-3-one.
    Paterson, I.; Norcross, R. D.; Ward, R. A.; Romea, P.; Lister, M. A. J. Am. Chem. Soc. 1994, 116, 11287-11314. Link to Publication
  86. Anti aldol reactions of lactate-derived ketones. Application to the total synthesis of (-)-ACRL Toxin IIIB.
    Paterson, I.; Wallace, D. J. Tetrahedron Lett. 1994, 35, 9477-9480. Link to Publication
  87. Stereocontrolled aldol additions to α-methylene-β-alkoxy aldehydes. Application to the synthesis of a C13-C25 segment of bafilomycin A1.
    Paterson, I.; Bower, S.; McLeod, M. D. Tetrahedron Lett. 1995, 36, 175-178. Link to Publication
  88. Mechanistic insights from ab initio calculations on a nitrogen analogue of the boron- mediated aldol reaction.
    Bernardi, A.; Gennari, C.; Goodman, J. M.; Leue, V.; Paterson, I. Tetrahedron 1995, 51, 4853-4866. Link to Publication
  89. Total synthesis of (-)-ebelactone A and B.
    Paterson, I.; Hulme, A. N.J. Org. Chem. 1995, 60, 3288-3300. Link to Publication
  90. Studies towards the total synthesis of the marine-derived immunosuppressant discodermolide. Stereoselective synthesis of a C9-C24 subunit.
    Paterson, I.; Schlapbach, A. Synlett 1995, 498-500. (Gilbert Stork Special Issue)
  91. The total synthesis of swinholide A. Part 1: A stereocontrolled synthesis of a C19-C32 segment.
    Paterson, I.; Cumming, J. G.; Ward, R. A.; Lamboley, S. Tetrahedron 1995, 51, 9393-9412. Link to Publication
  92. The total synthesis of swinholide A. Part 2: A stereocontrolled synthesis of a C1-C15 segment.
    Paterson, I.; Smith, J. D. Ward, R. A. Tetrahedron1995, 51, 9413-9436. Link to Publication
  93. The total synthesis of swinholide A. Part 3: Fragment coupling studies leading to a stereocontrolled synthesis of (-)-pre-swinholide A.
    Paterson, I.; Ward, R. A.; Smith, J. D.; Cumming, J. G.; Yeung, K.-S. Tetrahedron 1995, 51, 9437-9466. Link to Publication
  94. The total synthesis of swinholide A. Part 4: Synthesis of swinholide A and iso-swinholide A from a protected version of the monomeric seco acid, pre-swinholide A.
    Paterson, I.; Yeung, K.-S.; Ward, R. A.; Smith, J. D.; Cumming, J. G.; Lamboley, S. Tetrahedron 1995, 51, 9467-9486. Link to Publication
  95. Total synthesis of bioactive marine macrolides.
    Norcross, R. D.; Paterson, I. Chem. Rev. 1995, 95, 2041-2114. Link to Publication
  96. A computational model for stereoselectivity in the boron-mediated aldol reactions of methyl ketones.
    Bernardi, A.; Gennari, C.; Goodman, J. M.; Paterson, I. Electronic Conference on Trends in Organic Chemistry (ECTOC-1), 1995, Eds. Rzepa, H.S., Goodman, J. M. (CD-ROM), Royal Society of Chemistry publications.
  97. The rational design and systematic analysis of asymmetric aldol reactions using enol borinates: applications of transition state computer modelling.
    Bernardi, A.; Gennari, C.; Goodman, J. M.; Paterson, I. Tetrahedron: Asymmetry 1995, 6, 2613-2636.
  98. Studies in macrolide synthesis: a sequential aldol / glycosylation approach to the synthesis of concanamycin A.
    Paterson, I.; McLeod, M. D. Tetrahedron Lett. 1995, 36, 9065-9068. Link to Publication
  99. Total synthesis of (-)-denticulatins A and B using efficient methods of acyclic stereocontrol.
    Paterson, I.; Perkins, M. V. Tetrahedron1996, 52, 1811-1834. Link to Publication
  100. Two complementary methods for the synthesis of the terminal N-alkenyl-N- methylformamide group found in cytotoxic marine macrolides.
    Paterson, I.; Cowden, C.; Watson, C. Synlett 1996, 209-211. Link to Publication
  101. Anti aldol reactions of α-alkoxymethyl ketones: application to the total synthesis of (+)-restricticin.
    Paterson, I.; Nowak, T. Tetrahedron Lett. 1996, 37, 8243-8246. Link to Publication
  102. Studies in marine macrolide synthesis: stereocontrolled synthesis of the AB- spiroacetal subunit of spongistatin 1 (altohyrtin A).
    Paterson, I.; Oballa, R. M.; Norcross, R. D. Tetrahedron Lett. 1996, 37, 8581-8584. Link to Publication
  103. Remote, 1,5-anti stereoinduction in the boron-mediated aldol reactions of β- oxygenated methyl ketones.
    Paterson, I.; Gibson. K. R.; Oballa, R. M. Tetrahedron Lett. 1996, 37, 8585-8588 Link to Publication.
  104. Studies towards the synthesis of the zaragozic acids: a novel epoxide cyclisation approach to the formation of the bicyclic acetal core.
    Paterson, I.; Feβner, K.; Finlay, M. R. V.; Jacobs, M. F. Tetrahedron Lett. 1996, 37, 8803-8806. Link to Publication
  105. Total Synthesis of Scytophycin C.
    Paterson, I.; Watson, C.; Yeung, K.-S.; Wallace, P. A.; Ward, R. A. J. Org. Chem. 1997, 62, 452-453. Link to Publication
  106. Studies in macrolide synthesis: a novel cyclodimerisation approach to the synthesis of elaiophylin using a double Stille cross-coupling reaction.
    Paterson, I.; Man, J. Tetrahedron Lett. 1997, 38, 695-698. Link to Publication
  107. Erythromycin Derivatives.
    Paterson, I. UK Patent Application 9700702.5. 15 Jan 1997.
  108. Asymmetric aldol reactions using boron enolates.
    Cowden, C. J.; Paterson, I. Organic Reactions 1997, 51, 1-200.
  109. Studies in macrolide synthesis: Stereocontrolled synthesis of a C1-C13 segment of concanamycin A.
    Paterson, I.; McLeod, M. D. Tetrahedron Lett. 1997, 38, 4183-4186. Link to Publication
  110. Studies towards the synthesis of the zaragozic acids: synthesis of the bicyclic acetal core of zaragozic acid C.
    Paterson, I.; Feβner, K.; Finlay, M. R. V. Tetrahedron Lett. 1997, 38, 4301-4304. Link to Publication
  111. Cancer drugs better than Taxol?
    Cowden, C. J.; Paterson, I. Nature 1997, 387, 238-239. Link to Publication
  112. Studies in marine macrolide synthesis: stereocontrolled synthesis of the F-ring subunit of spongistatin 1 (altohyrtin A).
    Paterson, I.; Keown, L. E. Tetrahedron Lett. 1997, 38, 5727-5730. Link to Publication
  113. Polyketide library synthesis: iterative assembly of extended polypropionates using (R)- and (S)-1-(benzyloxy)-2-methylpentan-3-one.
    Paterson, I.; Scott. J. P. Tetrahedron Lett. 1997, 38, 7441-7444. Link to Publication
  114. Polyketide library synthesis: conformational control in extended polypropionates.
    Paterson, I.; Scott. J. P. Tetrahedron Lett. 1997, 38, 7445-7448. Link to Publication
  115. Studies in marine macrolide synthesis: synthesis of the C1-C15 subunit of spongistatin 1 (altohyrtin A) and 15,16-anti aldol coupling reactions.
    Paterson, I.; Oballa, R. M. Tetrahedron Lett. 1997, 38, 8241-8244. Link to Publication
  116. Studies in marine macrolide synthesis: synthesis of a C16-C28 subunit of spongistatin 1 (altohyrtin A) incorporating the CD-spiroacetal moiety.
    Paterson, I.; Wallace, D. J.; Gibson, K. R. Tetrahedron Lett. 1997, 38, 8911-8914. Link to Publication
  117. Polyketide synthesis using the boron-mediated, anti-aldol reactions of lactate-derived ketones: total synthesis of (-)-ACRL Toxin IIIB.
    Paterson, I.; Wallace, D. J.; Cowden, C. J. Synthesis 1998, 639-652. (Symposium-In-Print on Natural Products Synthesis)
  118. Epoxides in asymmetric synthesis. Enantioselective opening by nucleophiles promoted by chiral transition metal complexes.
    Paterson, I.; Berrisford, D. J. Organic Synthesis Highlights, Vol III, Mulzer, J., Waldmann, H., Eds., pp 62-66, Wiley-VCH, Weinheim, 1998.
  119. The total synthesis of scytophycin C. Part 1: Stereocontrolled synthesis of the protected C1-C32 seco acid.
    Paterson, I.; Yeung, K.-S.; Watson, C.; Ward, R. A.; Wallace, P. A. Tetrahedron 1998, 54, 11935-11954. Link to Publication
  120. The total synthesis of scytophycin C. Part 2: Synthesis of scytophycin C from the protected seco acid.
    Paterson, I.; Watson, C.; Yeung, K.-S.; Ward, R. A.; Wallace, P. A. Tetrahedron 1998, 54, 11955-11970. Link to Publication
  121. A facile oxidation/deprotection of electron rich silyl ethers using DDQ.
    Paterson, I.; Cowden, C. J.; Rahn, V. S.; Woodrow, M. D. Synlett 1998, 915-917. Link to Publication
  122. Studies in marine macrolide synthesis: stereocontrolled synthesis of the C1-C11 and C15-C27 subunits of aplyronine A.
    Paterson, I.; Cowden, C. J.; Woodrow, M. D. Tetrahedron Lett. 1998, 39, 6037-6040. Link to Publication
  123. Studies in marine macrolide synthesis: construction of a 24-membered macrocyclic intermediate for aplyronine A.
    Paterson, I.; Woodrow, M. D.; Cowden, C. J. Tetrahedron Lett. 1998, 39, 6041-6044. Link to Publication
  124. Towards the total synthesis of phorboxazoles A and B: stereocontrolled synthesis of a C20-C32 subunit.
    Paterson, I.; Arnott, E. A. Tetrahedron Lett. 1998, 39, 7185-7188. Link to Publication
  125. Studies in marine macrolide synthesis: synthesis of a fully functionalised C1-C28 subunit of spongistatin 1 (altohyrtin A).
    Paterson, I.; Wallace, D. J.; Oballa, R. M. Tetrahedron Lett. 1998, 39, 8545-8548. Link to Publication
  126. Stereocontrolled synthesis of polyketide libraries: boron-mediated aldol reactions with aldehydes on solid support.
    Gennari. C.; Ceccarelli, S.;Piarulli, U.;Aboutayab, K.;Donghi, M.; Paterson, I. Tetrahedron 1998, 54, 14999-15016. Link to Publication
  127. Anti aldol reactions of lactate-derived ketones. Application to the total synthesis of (-)-tetrahydrolipstatin.
    Paterson, I.; Doughty, V. A. Tetrahedron Lett. 1999, 40, 393-394. Link to Publication
  128. Laboratory emulation of polyketide biosynthesis: an iterative, aldol-based, synthetic entry to polyketide libraries using (R)- and (S)-1-(benzyloxy)-2- methylpentan-3-one, and conformational aspects of extended polypropionates.
    Paterson, I.; Scott, J. P. J. Chem. Soc., Perkin Trans. 1 1999, 1003-1014. Link to Publication
  129. Total synthesis of elaiolide using a copper(I)-promoted Stille cyclodimerization reaction.
    Paterson, I.; Lombart, H.-G.; Allerton, C. Org. Lett. 1999, 1, 19-22. Link to Publication
  130. Studies towards the synthesis of lophotoxin and pukalide: synthesis of the 14- membered macrocyclic core and some acyclic structural analogues.
    Paterson, I.; Brown, R. E.; Urch, C. Tetrahedron Lett. 1999, 40, 5807-5810. Link to Publication
  131. Synthesis of cytotoxic marine macrolides: an aldol-based approach to spongistatin 1 (altohyrtin A).
    Paterson, I.; Gibson, K. R.; Keown, L. E.; Norcross, R. D.; Oballa, R. M.; Wallace, D. J. Current Trends in Organic Synthesis, Scolastico, C., Nicotra, F., Eds., pp 299-306, Plenum, New York, 1999.
  132. Total synthesis of the antimicrotubule agent (+)-discodermolide using boron-mediated aldol reactions of chiral ketones.
    Paterson, I.; Florence, G. J.; Gerlach, K.; Scott, J. P. Angew. Chem. Int. Ed. 2000, 39, 377-380. Angew. Chem. 2000, 112, 385-388. Link to Publication
  133. Stereocontrolled aldol reactions in the total synthesis of polyketide natural products.
    Paterson, I.; Cowden, C. J.; Wallace, D. J. Modern Carbonyl Chemistry, Otera, J., Ed., pp 249-297, Wiley-VCH, Weinheim, 2000.
  134. Total synthesis of (+)-concanamycin F.
    Paterson, I.; Doughty, V. A.; McLeod, M. D.; Trieselmann, T. Angew. Chem. Int. Ed. 2000, 39, 1308-1317. Angew. Chem. 2000, 112, 1364-1368. Link to Publication
  135. Studies in marine polypropionate synthesis: total synthesis of (-)-baconipyrone C.
    Paterson, I.; Chen, D. Y.-K.; Acena, J. L.; Franklin, A. F. Org. Lett. 2000, 2, 1513- 1516. Link to Publication
  136. A combinatorial approach to polyketide-type libraries via iterative asymmetric aldol reactions performed on solid support.
    Paterson, I.; Donghi, M.; Gerlach, K. Angew. Chem. Int. Ed. 2000, 39, 3315-3319. Angew. Chem. 2000, 112, 3453-3457. Link to Publication
  137. Synthesis of (+)-discodermolide and analogues by control of asymmetric induction in aldol reactions of γ-chiral (Z)-enals.
    Paterson, I.; Florence, G. J. Tetrahedron Lett. 2000, 41, 6935-6939. Link to Publication
  138. Asymmetric aldol reactions using boron enolates: applications to polyketide synthesis.
    Paterson, I.; Doughty, V. A.; Florence, G. J.; Gerlach, K.; McLeod, M. D.; Scott, J. P.; Trieselmann, T. ACS Symposium Series 783, Organoboranes for Syntheses, Ramachandran, P. V., Brown, H. C. Ed., Ch 14, pp 195-206, American Chemical Society, Washington, DC, 2000.
  139. Synthesis of the macrocyclic core of laulimalide.
    Paterson, I.; De Savi, C.; Tudge, M. Org. Lett. 2001, 3, 213-216. Link to Publication
  140. Remote 1,5-stereoinduction in boron aldol reactions of methyl ketones: application to the convergent assembly of the 1,3-polyol sequence of (+)-roxaticin.
    Paterson, I.; Collett, L. A. Tetrahedron Lett. 2001, 42, 1187-1191. Link to Publication
  141. Total synthesis of the callipeltoside aglycon.
    Paterson, I.; Davies, R. D. M.; Marquez, R. Angew. Chem. Int. Ed. 2001, 40, 603- 607. Angew. Chem. 2001, 113, 623-627. Link to Publication
  142. A practical synthesis of (+)-discodermolide and analogues: fragment union by complex aldol reactions.
    Paterson, I.; Florence, G. J.; Gerlach, K.; Scott, J. P.; Sereinig, N. J. Am. Chem. Soc. 2001, 123, 9535-9544. Link to Publication
  143. Total synthesis of the microtubule-stabilizing agent (-)-laulimalide.
    Paterson, I.; De Savi, C.; Tudge, M. Org. Lett. 2001, 3, 3149-3152. Link to Publication
  144. Stereocontrolled total synthesis of (+)-altohyrtin A/spongistatin 1.
    Paterson, I.; Chen, D. Y.-K.; Coster, M. J.; Acena, J. L.; Bach, J.; Gibson, K. R.; Keown, L. E.; Oballa, R. M.; Trieselmann, T.; Wallace, D. J.; Hodgson, A.; Norcross, R. D. Angew. Chem. Int. Ed. 2001, 40, 4055-4060. Angew. Chem. 2001, 113, 4179-4184. Link to Publication
  145. Boron-mediated aldol reactions of ethyl ά-(N,N)-dibenzylamino ketones: control of enolisation geometry and π-facial selectivity.
    Paterson, I.; Mackay, A. C. Tetrahedron Lett. 2001, 42, 9269-9272. Link to Publication
  146. Total synthesis of siphonarin B and dihydrosiphonarin B.
    Paterson, I.; Chen, D. Y. K.; Franklin, A. S. Org. Lett. 2002, 4, 391-394. Link to Publication
  147. Total synthesis of altohyrtin A (spongistatin 1): an alternative synthesis of the CD-spiroacetal subunit.
    Paterson, I.; Coster, M. J. Tetrahedron Lett. 2002, 43, 3285-3289. Link to Publication
  148. Towards the combinatorial synthesis of polyketide libraries: Asymmetric aldol reactions with alpha-chiral aldehydes on solid support.
    Paterson, I.; Temal-Laib, T. Org. Lett. 2002, 4, 2473-2476. Link to Publication
  149. Studies in marine macrolide synthesis: stereocontrolled synthesis of a C21-C34 subunit of the aplyronines.
    Paterson, I.; Blakey, S. B.; Cowden, C. J. Tetrahedron Lett. 2002, 43, 6005-6008. Link to Publication
  150. Actin-binding marine macrolides: Total synthesis and biological importance.
    Yeung, K. S.; Paterson, I. Angew. Chem. Int. Ed. 2002, 41, 4632-4653. Link to Publication
  151. 1,6-asymmetric induction in boron-mediated aldol reactions: Application to a practical total synthesis of (+)-discodermolide.
    Paterson, I.; Delgado, O.; Florence, G. J.; Lyothier, I.; Scott, J. P.; Sereinig, N. Org. Lett. 2003, 5, 35-38. Link to Publication
  152. Stereocontrolled total synthesis of (+)-leucascandrolide A.
    Paterson, I.; Tudge, M. Angew. Chem. Int. Ed. 2003, 42, 343-348. Link to Publication
  153. A highly enantioselective catalyst for the asymmetric Nozaki-Hiyama-Kishi reaction of allylic and vinylic halides.
    Berkessel, A.; Menche, D.; Sklorz, C. A.; Schroeder, M.; Paterson, I. Angew. Chem. Int. Ed. 2003, 42, 1032-1035. Link to Publication
  154. Toward the synthesis of peloruside A: Fragment synthesis and coupling studies.
    Paterson, I.; Di Francesco, M. E.; Kuhn, T. Org. Lett. 2003, 5, 599-602. Link to Publication
  155. Synthesis and biological evaluation of spongistatin/altohyrtin analogues: E-ring dehydration and C46 side-chain truncation.
    Paterson, I.; Acena, J. L.; Bach, J.; Chen, D. Y. K.; Coster, M. J. J. Chem. Soc., Chem. Commun. 2003, 4, 462-463. Link to Publication
  156. Discodermolide interferes with the binding of tau protein to microtubules.
    Kar, S.; Florence, G. J.; Paterson, I.; Amos, L. A. FEBS. Lett. 2003, 539, 34-36. Link to Publication
  157. Toward the total synthesis of phorboxazole A: synthesis of an advanced C4-C32 subunit using the Jacobsen hetero Diels-Alder reaction.
    Paterson, I.; Luckhurst, C. A. Tetrahedron Lett. 2003, 44, 3749-3754. Link to Publication
  158. Toward the synthesis of reidispongiolide A: Stereocontrolled synthesis of the C17-C22 and C23-C35 degradation fragments.
    Paterson, I.; Ashton, K.; Britton, R.; Knust, H. Org. Lett. 2003, 5, 1963-1966. Link to Publication
  159. A fully stereocontrolled total synthesis of (+)-leucascandrolide A.
    Paterson, I.; Tudge, M. Tetrahedron. 2003, 59, 6833-6849. Link to Publication
  160. The development of a practical total synthesis of discodermolide, a promising microtubule-stabilizing anticancer agent.
    Paterson, I.; Florence, G. J. Eur. J. Org. Chem. 2003, 12, 2193-2208. Link to Publication
  161. Stereocontrolled total synthesis of (-)-callipeltoside A.
    Paterson, I.; Davies, R. D. M.; Heimann, A. C.; Marquez, R.; Meyer, A. Org. Lett. 2003, 23, 4477-4480. Link to Publication
  162. Synthesis of novel discodermolide analogues with modified hydrogen-bonding donor/acceptor sites.
    Paterson, I.; Delgado, O. Tetrahedron Lett. 2003, 44, 8877-8882. Link to Publication
  163. Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 4: Preparation of fragment C7-24.
    Mickel, S. J.; Paterson, I.; Florence, G. et al. Org. Process Res. Dev. 2004, 8, 113-121. Link to Publication
  164. Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 5: Linkage of fragments C1-6 and C7-24 and Finale.
    Mickel, S. J.; Paterson, I.; Florence, G.; Lyothier, I. et al. Org. Process Res. Dev. 2004, 8, 122-130. Link to Publication
  165. Synthesis of novel 11-desmethyl analogues of laulimalide by Nozaki-Kishi coupling.
    Paterson, I.; Bergmann, H.; Menche, D.; Berkessel, A. Org. Lett. 2004, 6, 1293-1295. Link to Publication
  166. Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae.
    Paterson, I.; Britton, R.; Delgado, O.; Wright, A. E. Chem. Commun. 2004, 6, 632-633. Link to Publication
  167. A quantitative evaluation of the effects of inhibitors of tubulin assembly on polymerization induced by discodermolide, epothilone B, and paclitaxel.
    Dabydeen, D. A.; Paterson, I.; Florence, G. J.; Hamel, E. Cancer Chemotherapy and Pharmacology. 2004, 53, 397-403. Link to Publication
  168. Studies towards the synthesis of superstolide A: An aldol-based construction of an advanced C1-C5/C20-C26 segment.
    Paterson, I.; Mackay, A. Synlett. 2004, 8, 1359-1362. Link to Publication
  169. Synthesis of antimicrofilament marine macrolides: Synthesis and configurational assignment of a C5-C16 degradation fragment of reidispongiolide A.
    Paterson, I.; Britton, R.; Ashton, K.; Knust, H.; Stafford, J. PNAS. 2004, 101, 11986-11991. Link to Publication
  170. Total synthesis and configurational assignment of (-)-dictyostatin, a microtubule-stabilizing macrolide of marine sponge origin.
    Paterson, I.; Britton, R.; Delgado, O.; Meyer, A.; Poullennec, K. G. Angew. Chem. Int. Ed. 2004, 43, 4629-4633. (Cover picture: Angew. Chem. Int. Ed. 2004, 43, 4537.) Link to Publication
  171. Phorboxazole B synthetic studies: construction of C(1-32) and C(33-46) subtargets.
    Paterson, I.; Steven, A.; Luckhurst, C. A. Org. Biomol. Chem. 2004, 2, 3026-3038. Link to Publication
  172. Total Synthesis of (+)-discodermolide: An Improved Endgame Exploiting a Still-Gennari Type Olefination with a C1-C8 Β-ketophosponate fragment.
    Paterson, I.; Lyothier, I. Org. Lett. 2004, 6(26), 4933-4936. Link to Publication
  173. A second generation Total Synthesis of (+)-Discodermolide: The Development of a Practical Route using Solely Substrate-Based Stereocontrol.
    Paterson, I.; Delgado, O.; Florence, G. J.; Lyothier, I.; O'Brien, M.; Scott, J. P.; Sereinig, N. J. Org. Chem. 2005, 70 (1), 150-160. Link to Publication
  174. Stereocontrolled Total Synthesis of (-)-Aurisides A and B.
    Paterson, I.; Florence, G. J; Heimann, A. C; Mackay, A. C. Angew. Chem. Int. Ed. 2005, 1130-1133. Link to Publication
  175. Design, synthesis and biological evaluation of novel, simplified analogues of laulimalide: modification of the side chain.
    Paterson, I.; Menche, D.; Hakansson A. E.; Longstaff, A.; Wong, D.; Barasoain, I.; Buey, R. M.; Diaz, J. F. Bioorg. Med. Chem. Lett. 2005, 15 (9), 2243-2247. Link to Publication
  176. Conformational studies and solution structure of laulimalide and simplified analogues using NMR spectroscopy and molecular modelling.
    Paterson, I.; Menche, D.; Britton, R.; Hakansson, A. E.; Silva-Martinez, M. A. Tetrahedron Lett. 2005, 46 (21), 3677-3682. Link to Publication
  177. The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the AB-spiroacetal segment.
    Paterson, I.; Coster, M. J.; Chen, D. Y.; Oballa, R. M.; Wallace, D. J.; Norcross, R. D. Org. Biomol. Chem. 2005, 3 (13), 2399-2409. Link to Publication
  178. The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the CD-spiroacetal segment.
    Paterson, I.; Coster, M. J.; Chen, D. Y.; Gibson, K. R.; Wallace, D. J. Org. Biomol. Chem. 2005, 3 (13), 2410-2419. Link to Publication
  179. The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the southern hemisphere EF segment.
    Paterson, I.; Coster, M. J.; Chen, D. Y.; Acena, J. L.; Bach, J.; Keown, L. E.; Trieselmann, T. Org. Biomol. Chem. 2005, 3 (13), 2420-2430. Link to Publication
  180. The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: fragment couplings, completion of the synthesis, analogue generation and biological evaluation.
    Paterson, I.; Chen, D. Y.; Coster, M. J.; Acena, J. L.; Bach, J.; Wallace, D. J. Org. Biomol. Chem. 2005, 3 (13), 2431-2440. Link to Publication
  181. Development of a third-generation total synthesis of (+)-discodermolide: an expedient Still-Gennari-type fragment coupling utilizing an advanced beta-ketophosphonate.
    Paterson, I.; Lyothier, I. J. Org. Chem. 2005, 70 (14), 5494-5507. Link to Publication
  182. Towards the combinatorial synthesis of spongistatin fragment libraries by using asymmetric aldol reactions on solid support.
    Paterson, I.; Gottschling, D.; Menche, D. Chem. Commun. (Camb). 2005, 28, 3568-3570. Link to Publication
  183. Toward the synthesis of spirastrellolide A: Construction of a tetracyclic C26-C40 subunit containing the DEF-bis-spiroacetal.
    Paterson, I.; Anderson, E. A.; Dalby, S. M.; Loiseleur, O. Org. Lett. 2005, 19, 4121-4124. Link to Publication
  184. Toward the synthesis of spirastrellolide A: Construction of two C1-C25 diastereomers containing the BC-spiroacetal.
    Paterson, I.; Anderson, E. A.; Dalby, S. M.; Loiseleur, O. Org. Lett. 2005, 19, 4125-4128. Link to Publication
  185. The renaissance of natural products as drug candidates.
    Paterson, I.; Anderson, E. A. Science 2005, 5747, 451-453. Link to Publication
  186. Synthesis of the C1-C21 southern hemisphere of the originally proposed structure of spirastrellolide A.
    Paterson, I.; Anderson, E. A.; Dalby, S. M. Synthesis 2005, 3225-3228. Link to Publication
  187. Advances in the total synthesis of biologically important marine macrolides.
    Yeung, K.-S.; Paterson, I. Chem. Rev. 2005, 105 (12), 4237-4313. Link to Publication
  188. Microtubule interactions with chemically diverse stabilizing agents: Thermodynamics of binding to the paclitaxel site predicts cytotoxicity.
    Buey, R. M.; Barasoain, I.; Jackson, E.; Meyer, A.; Giannakakou. P.; Paterson, I.; Moobery, S.; Andreu, J. M,; Diaz, J. F. Chemistry & Biology 2005, 12 (12), 1269-1279. Link to Publication
  189. Total Synthesis and Stereochemical Reassignment of (+)-Dolastatin 19.
    Paterson, I.; Findlay, A. D.; Florence, G. J. Org. Lett. 2006, 8, 2131-2134. Link to Publication
  190. Synthesis of the DEF-bis-spiroacetal of spirastrellolide A exploiting a double asymmetric dihydroxylation/spiroacetalisation strategy.
    Paterson, I.; Anderson, E. A.; Dalby, S. M.; Lim, J. H.; Maltas, P.; Moessner, C. Chem. Commun. 2006, 4186-4188. Link to Publication
  191. The Tubulin-Bound Conformation of Discodermolide Derived by NMR Studies in Solution Supports a Common Pharmacophore Model for Epothilone and Discodermolide.
    Sanchez-Pedregal, V. M.; Kubicek, K.; Meiler, J.; Lyothier, I. Paterson, I.; Carlomagno, T. Angew. Chem. Int. Ed. 2006, 44, 7388-7394. Link to Publication
  192. Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid.
    Paterson, I.; Gardner, N. Chem. Commun. 2007, 1, 47-49. Link to Publication
  193. Total synthesis of polyketides using asymmetric aldol reactions.
    Paterson, I. Asymmetric Synthesis [Wiley-VCH Verlag GmbH&Co.], 2007, 278-282.
  194. Synthesis and biological evaluation of novel analogues of dictyostatin.
    Paterson, I.; Gardner, N. M.; Poullennec, K. G.; Wright, A. E. Bioorg. Med. Chem. Lett. 2007, 2443-2447y, S.; Andreu, J. M,; Diaz, J. F. Chemistry & Biology 2005, 12 (12), 1269-1279.ation" />
  195. Synthesis of two diastereomeric C1-C22 fragments of spirastrellolide A.
    Paterson, I.; Anderson, E. A.; Dalby, S. M.; Genovino, J.; Lim, J. H.; Moessner, C. Chem Commun. 2007, 1852-1854. Link to Publication
  196. Total synthesis and stereochemical reassignment of (+)-dolastatin 19, a cytotoxic marine macrolide isolated from Dolabella auricularia.
    Paterson, I.; Findlay, A. D.; Florence, G. J. Tetrahedron 2007, 5806-5819. Link to Publication
  197. Progress toward a total synthesis of spirastrellolide A.
    Paterson, I.; Anderson, E. A.; Dalby, S. M.; Lim, J. H.; Loiseleur, O.; Maltas, P.; Moessner, C. Pure Appl. Chem. 2007, 79, 467-823. Link to Publication
  198. Total Synthesis of (-)-Reidispongiolide A, an Actin-Targeting Marine Macrolide.
    Paterson, I.; Ashton, K.; Britton, R.; Cecere, G.; Chouraqui, G.; Florence, G. J.; Stafford, J. Angew. Chem. Int. Ed. 2007, 32, 6167-6171. Link to Publication
  199. Synthesis of an Advanced C10-C32 Spiroacetal Fragment and Assignment of the Absolute Configuration of Spirangien A.
    Paterson, I.; Findlay, A. D.; Anderson, E. A. Angew. Chem. Int. Ed. 2007, 35, 6699-6702.Link to Publication
  200. Total Synthesis of (-)-Reidispongiolide A, an Actin-Targeting Macrolide Isolated from the Marine Sponge Reidispongia coerulea.
    Paterson, I.; Ashton, K.; Britton, R.; Cecere, G.; Chouraqui, G.; Florence, G. J.; Knust, H.; Stafford, J. Chemistry - An Asian Journal, 2008, 367-387. Link to Publication
  201. Total synthesis of pteridic acids A and B.
    Paterson, I.; Anderson, E. A.; Findlay, A. D.; Knappy, C. S. Tetrahedron 2008, 64, 4768-4777. Link to Publication
  202. Total Synthesis of Spirastrellolide A Methyl Ester - Part 1: Synthesis of an Advanced C17-C40 Bis-spiroacetal Subunit.
    Paterson, I.; Anderson, E. A,; Dalby, S. M; Lim, J. H.; Genovino, J.; Maltas, P.; Moessner, C. Angew. Chem. Int. Ed. 2008, 3016-3020. Link to Publication
  203. Total Synthesis of Spirastrellolide A Methyl Ester - Part 2: Subunit Union and Completion of the Synthesis.
    Paterson, I.; Anderson, E. A,; Dalby, S. M; Lim, J. H.; Genovino, J.; Maltas, P.; Moessner, C. Angew. Chem. Int. Ed. 2008, 3021-3025. Link to Publication
  204. Development of practical syntheses of the marine anticancer agents discodermolide and dictyostatin.
    Florence, G. J.; Gardner, N. M.; Paterson, I. Nat. Prod. Rep. 2008, 25, 342-375.Link to Publication
  205. Synthetic Mimetics of Actin-Binding Macrolides: Rational Design of Actin-Targeted Drugs.
    Perrins, R. D.; Cecere, G.; Paterson, I.; Marriot, G. Chemistry & Biology 2008, 15, 3, 287-294. Link to Publication
  206. Synthesis and biological evaluation of 10,11-dihydrodictyostatin, a potent analogue of the marine anticancer agent dictyostatin.
    Paterson, I.; Gardner, N. M.; Poullennec, K. G.; Wright, A. E. J. Nat. Prod. 2008, 71, 3, 364-369. Link to Publication
  207. Total Synthesis of (-)-Saliniketals A and B.
    Paterson, I.; Razzak, M.; Anderson, E. A. Org. Lett. 2008, 10(15), 3295-3298. Link to Publication
  208. Total synthesis of cytotoxic marine macrolides: Callipeltoside A, aurisides A and B, and dolastatin 19.
    Paterson, I.; Findlay, A. D. Pure Appl. Chem. 2008, 80, 8, 1773-1782. Link to Publication
  209. The Bound Conformation of Microtubule-Stabilizing Agents: NMR Insights into the Bioactive 3D Structure of Discodermolide and Dictyostatin.
    Canales, A.; Matesanz, R.; Gardner, N. M.; Andreu, J. M.; Paterson, I.; Diaz, J. F.; Jimenez-Barbero, J. Chem. Eur. J. 2008, 14, 25, 7557-7569. Link to Publication
  210. Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide.
    Paterson, I.; Naylor, G. J.; Wright, A. E. Chem. Commun. 2008, 4628-4630. Link to Publication
  211. Total synthesis of the marine macrolide (+)-neopeltolide.
    Paterson, I.; Miller, N. A. Chem. Commun. 2008, 37, 4708-4710. Link to Publication
  212. Total synthesis of (-)-spirangien A and its methyl ester.
    Paterson, I.; Findlay, A. D.; Noti, C. Chem. Commun. 2008, 4, 6408-6410. Link to Publication
  213. Total synthesis and biological evaluation of potent analogues of dictyostatin: Modification of the C2-C6 dienoate region.
    Paterson, I.; Gardner, N. M.; Guzman, E.; Wright, A. E. Bioorg. Med. Chem. Lett. 2008, 18, 6268-6272. Link to Publication
  214. Toward the Total Synthesis of the Brasilinolides: Stereocontrolled Assembly of a C1-C19 Polyol Segment.
    Paterson, I.; Mühlthau, F. A.; Cordier, C. J.; Housden, M. P.; Burton P. M.; Loiseleur, O. Org. Lett. 2009, 11, 353-356. Link to Publication
  215. Toward the Total Synthesis of the Brasilinolides: Construction of a Differentially Protected C20-C38 Segment.
    Paterson, I.; Burton P. M.; Cordier, C. J.; Housden, M. P.; Mühlthau, F. A.; Loiseleur, O. Org. Lett. 2009, 11, 693-696.Link to Publication
  216. Total Synthesis of (-)-Spirangien A, an Antimitotic Polyketide Isolated from the Myxobacterium Sorangium Cellulosum.
    Paterson, I.; Findlay, A. D.; Noti, C. Chem. Asian J. 2009, 594-611. Link to Publication
  217. The Chemical Synthesis of Discodermolide
    Paterson, I.; Florence, G. J. Top. Curr. Chem. 2009, 286, 73. Link to Publication
  218. Total synthesis of novel dictyostatin analogs and hybrids as microtubule-stabilizing anticancer agents.
    Paterson, I.; Gardner, N. M.; Naylor, G. N. Pure Appl. Chem. 2009, 169-180. Link to Publication
  219. Total synthesis and biological evaluation of novel C2-C6 region analogues of dictyostatin.
    Paterson, I.; Gardner, N. M.; Guzman, E.; Wright, A. E. Bioorg Med. Chem. 2009, 2282-2289. Link to Publication
  220. Synthesis and stereochemical determination of the spirastrellolides.
    Paterson, I.; Dalby, S. M. Nat. Prod. Rep. 2009, 26, 865-873. Link to Publication
  221. Recent Advances in the Total Synthesis of Polyketide Natural Products as Promising Anticancer Agents.
    Paterson, I.; Findlay, A. F. Australian J. Chem. 2009, 62, 624-638. Link to Publication
  222. Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin.
    Paterson, I.; Naylor, G. J.; Fujita, T.; Guzman, E.; Wright, A. E. Chem. Commun. 2010, 46, 261-263. Link to Publication
  223. Synthetic Studies towards Iriomoteolide 1a: Stereocontrolled Construction of C1-C9 and C11-C23 Segments Using Lactate Aldol Chemistry
    Paterson, I.; Rubenbauer, P. Synlett. 2010, 4, 571-574. Link to Publication
  224. Total Synthesis and Configurational Validation of (+)-Phorbaside A
    Paterson, I.; Paquet, T. Org. Lett. 2010, 12, 2158-2161. Link to Publication
  225. Total synthesis of (-)-dictyostatin, a microtubule-stabilising anticancer macrolide of marine sponge origin
    Paterson, I.; Britton, R.; Delgado, O.; Gardner, N. M.; Meyer, A.; Naylor, G. J.; Poullennec, K. J. Tetrahedron 2010, 66, 6534-6545. Link to Publication
  226. Molecular Recognition of Peloruside A by Microtubules. The C24 Primary Alcohol is Essential for Biological Activity
    Pera, B.; Razzak, M.; Trigili, C.; Pineda, O.; Canales, A.; Buey, R.; Jiménez-Barbero, J.; Northcote, P. T.; Paterson, I.; Barasoain, I.; Díaz, J. F. ChemBioChem 2010, 11, 1669-1678. Link to Publication
  227. Synthesis of polyketide natural products and analogs as promising anticancer agents.
    Dalby, S. M.; Paterson, I. Curr. Opin. Drug Discov. Devel. 2010, 13, 777-794.
  228. Synthesis of the C1-C13 Tetraenoate Subunit of the Chivosazoles
    Paterson, I.; Kan, S. B. J.; Gibson, L. J. Org. Lett. 2010, 12, 3724-3727. Link to Publication
  229. The stereochemical assignment of acyclic polyols: a computational study of the NMR data of a library of stereopentad sequences from polyketide natural products
    Smith, S. G.; Channon, J. A.; Paterson, I.; Goodman, J. M. Tetrahedron 2010, 66, 6437-6444. Link to Publication
  230. Synthesis of the C15-C35 Northern Hemisphere Subunit of the Chivosazoles
    Paterson, I.; Gibson, L. J.; Kan, S. B. J. Org. Lett. 2010, 12, 5530-5533. Link to Publication
  231. Total Synthesis and Biological Evaluation of a Series of Macrocyclic Hybrids and Analogues of the Antimitotic Natural Products Dictyostatin, Discodermolide, and Taxol
    Paterson, I.; Naylor, G. J.; Gardner, N. M.; Guzman, E.; Wright, A. E. Chem. Asian J. 2011, 6, 459-473. Link to Publication
  232. Leiodermatolide, a Potent Antimitotic Macrolide from the Marine Sponge Leiodermatium sp.
    Paterson, I.; Dalby, S. M.; Roberts, J. C.; Naylor, G. J.; Guzman, E. A.; Isbrucker, R.; Pitts, T. P.; Linley, P.; Dilianska, D.; Reed, J. K.; Wright, A. E. Angew. Chem. Int. Ed. 2011, 50, 1-6. Link to Publication
  233. Structure-Activity Studies of the Pelorusides: New Congeners and Semi-Synthetic Analogues
    Singh, A. J.; Razzak, M.; Teesdale-Spittle, P.; Gaitanos, T. N.; Wilmes, A.; Paterson, I.; Goodman, J. M.; Miller, J. H.; Northcote, P. T. Org. Biomol. Chem. 2011, 9, 4456-4466. Link to Publication
  234. Insights into the Interaction of Discodermolide and Docetaxel with Tubulin. Mapping the Binding Sites of Microtubule-Stabilizing Agents by Using an Integrated NMR and Computational Approach
    Canales, A.; Rodríguez-Salarichs, J.; Trigili, C.; Nieto, L.; Coderch, C.; Andreu, J. M., Paterson, I.; Jiménez-Barbero, J.; Díaz, J. F. ACS Chem. Biol. 2011, 6, 789-799. Link to Publication
  235. Strategy evolution in the total synthesis of spirastrellolide A methyl ester
    Paterson, I.; Dalby, S. M.; Maltas, P. Isr. J. Chem. 2011, 51, 406-419. Link to Publication
  236. Synthesis of the Macrocyclic Core of Leiodermatolide
    Paterson, I.; Paquet, T.; Dalby, S. M. Org. Lett. 2011, 13, 4398-4401. Link to Publication
  237. Stereocontrolled total synthesis of (+)-concanamycin F: the strategic use of boron-mediated aldol reactions of chiral ketones
    Paterson, I.; Steadman neé Doughty, V. A.; McLeod, M. D.; Trieselmann, T. Tetrahedron 2011, 67, 10119-10128. Link to Publication
  238. Synergistic interactions between peloruside A and other microtubule-stabilizing and destabilizing agents in cultured human ovarian carcinoma cells and murine T cells
    Wilmes, A.; O'Sullivan, D.; Chan, A.; Chandrahasen, C.; Paterson, I.; Northcote, P. T.; La Flamme, A. C.; Miller, J. H. Cancer Chemoth Pharm 2011, 117-126. Link to Publication
  239. Total synthesis of Alotaketal A
    Xuan, M.; Paterson, I.; Dalby, S. M. Org. Lett. 2012, 14, 5492-5495. Link to Publication
  240. The stereocontrolled total synthesis of spirastrellolide A methyl ester. Expedient construction of the key fragments
    Paterson I, Anderson EA, Dalby SM, Lim JH, Maltas P, Loiseleur O, Genovino J, Moessner C Org. Biomol. Chem. 2012, 10, 5861-5872. Link to Publication
  241. The stereocontrolled total synthesis of spirastrellolide A methyl ester. Fragment coupling studies and completion of the synthesis
    Paterson, I.; Anderson, E.A.; Dalby, S. M.; Lim, J. H.; Maltas, P. Org. Biomol. Chem. 2012, 10, 5873-5886. Link to Publication
  242. A second-generation total synthesis of spirastrellolide A methyl ester
    Paterson, I.; Maltas, P.; Dalby, S. M.; Lim, J. H.; Anderson, E. A. Angew. Chem. Int. Ed. 2012, 51, 2749-2753. Link to Publication
  243. Total Synthesis of Aplyronine C
    Paterson, I.; Fink, S. J.; Lee, L. Y.; Atkinson, S. J.; Blakey, S. B. Org. Lett. 2013, 15, 3118-3121. Link to Publication
  244. Total synthesis of (+)-Spirastrellolide A Methyl Ester: Challenges and discoveries
    Paterson, I.; Maltas, P.; Anderson, E. A. Pure and Applied Chemistry 2013, 85, 1133-1147. Link to Publication
  245. Total Synthesis of (-)-Rhizopodin
    Dalby, S. M., Goodwin-Tindall, J.; Paterson, I. Angew. Chem. Int. Ed. 2013, 52, 6517-6521. Link to Publication
  246. Synthesis of the C1-C11 western fragment of Madeirolide A
    Paterson, I.; Haslett, G. W. Org. Lett. 2013, 15, 1338-1341. Link to Publication
  247. The Impact of the Mukaiyama Aldol Reaction in Total Synthesis
    Kan, S. B. J.; Ng, K. K.-H.; Paterson, I. Angew. Chem. Int. Ed. 2013, 52, 9097-9108. Link to Publication
  248. Total synthesis of the antimitotic marine macrolide (-)-leiodermatolide
    Paterson, I.; Ng, K. K.-H.; Williams, S.; Millican, D. C.; Dalby, S. M. Angew. Chem. Int. Ed. 2014, 53, 2692-2695. Link to Publication
  249. Molecular Recognition of Epothilones by Microtubules and Tubulin Dimers Revealed by Biochemical and NMR Approaches
    Canales, A.; Nieto, L.; Rodríguez-Salarichs, J.; Sanchez-Murcia, P. A.; Coderch, C.; Cortes-Cabrera, A.; Paterson, I.; Carlomagno, T.; Gago, F.; Andreu, J. M.; Altmann, K. H.; Jimenez-Barbero, J.; Diaz, J. F.ACS Chem. Biol. 2014, 9, 1033-1043. Link to Publication
  250. Total Synthesis of Jiadifenolide
    Paterson, I.; Xuan, M.; Dalby, S. M. Angew. Chem. Int. Ed. ASAP, . Link to Publication
  251. Structural and Biochemical Studies of Actin in Complex with Synthetic Macrolide Tail Analogues
    Pereira, J. H.; Petchprayoon, C.; Hoepker, A. C.; Moriarty, N. W.; Fink, S. J.; Cecere, G.; Paterson, I.; Adams, P. D.; Marriot, G. ChemMedChem 2014, 9, 2286-2293. Link to Publication
  252. Synthetic studies toward the brasilinolides: controlled assembly of a protected C1-C38 polyol based on fragment union by complex aldol reactions
    Paterson, I.; Housden, M. P.; Cordier, C. J.; Burton, P. M.; Mühlthau, F. A.; Loiseleur, O. Org. Biomol. Chem. 2015, 13, 5716-5733. Link to Publication
  253. Strategy Evolution in the Total Synthesis of (-)-Leiodermatolide
    Paterson, I.; Williams, S.Israel J. Org. Chem. 2016, Link to Publication
  254. Toward the stereochemical assignment and synthesis of hemicalide: DP4 GIAO-NMR analysis and synthesis of a reassigned C16-C28 subunit
    MacGregor, C.I., Han, B.Y., Goodman, J.M., Paterson, I. Chem. Commun. 2016, 52, 4632-4635. Link to Publication
  255. An Expedient Total Synthesis of Chivosazole F: an Actin-Binding Antimitotic Macrolide from the Myxobacterium Sorangium Cellulosum.
    Williams, S., Jin, J., Kan, S.B.J., Li, M., Gibson, L.J., Paterson, I. Angew. Chem. Int. Ed. 2017, 18, 645-649Link to Publication
  256. Structural Basis of Microtubule Stabilization by Discodermolide.
    AE Prota, K Bargsten, M Redondo-Horcajo, AB Smith, C-PH Yang, HM McDaid, I Paterson, SB Horwitz, J Fernando Díaz, MO Steinmetz Chem. Bio. Chem. 2017, 56, 605 Link to Publication
  257. Zampanolide, a microtubule-stabilizing agent, is active in resistant cancer cells and inhibits cell migration.
    Field, J.J, Northcote, P.T., Paterson, I., Altmann, K.-H., Daz, J.F., Miller, J.H. International Journal of Molecular Sciences 2017, 18, 971 Link to Publication
  258. Induction of accelerated senescence by the microtubule-stabilizing agent peloruside A.
    Chan, A., Gilfillan, C., Templeton, N., Paterson, I., Northcote, P.T., Miller, J.H. Investigational New Drugs 2017, 35, 706 Link to Publication
  259. A synthesis-enabled relative stereochemical assignment of the C1-C28 region of hemicalide.
    Han, B.Y., Lam, N.Y.S., MacGregor, C.I., Goodman, J.M., Paterson, I. Chem. Comm. 2018, 54, 3247 Link to Publication
  260. Toward the total synthesis of patellazole B: Synthesis of an advanced C1-C25 fragment corresponding to the macrocyclic skeleton.
    Phillips, A.W., Anketell, M.J., Balan, T., Lam, N.Y.S., Williams, S., Paterson, I. Org. Biomol. Chem. 2018, 16, 6908 Link to Publication
  261. Toward aplyronine payloads for antibody-drug conjugates: Total synthesis of aplyronines A and D.
    Anzicek, N., Williams, S., Housden, M.P., Paterson, I. Org. Biomol. Chem. 2018, 16, 1343 Link to Publication
  262. Challenges and discoveries in the total synthesis of complex polyketide natural products.
    Paterson, I., Lam, N.Y.S. Journal of Antibiotics 2018, 71, 215 Link to Publication
  263. A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.
    Menchon, G., Prota, A.E., Lucena-Agell, D., Bucher, P., Jansen, R., Irschik, H., Mller, R., Paterson, I., Daz, J.F., Altmann, K.-H., Steinmetz, M.O. Nature Comm. 2018, 9, 2106 Link to Publication
  264. A counterintuitive stereochemical outcome from a chelation-controlled vinylmetal aldehyde addition leads to the configurational reassignment of phormidolide A.
    Lam, N.Y.S., Muir, G., Challa, V.R., Britton, R., Paterson, I. Chem. Comm. 2019, 55, 9717 Link to Publication
  265. A Unified Total Synthesis of the Actinoallolides, a Family of Potent Anti-Trypanosomal Macrolides.
    Anketell, M.J., Sharrock, T.M., Paterson, I. Angewandte Chemie - International Edition 2020, 59, 1572 Link to Publication
  266. Stereocontrolled Synthesis as an Enabling Tool for the Configurational Assignment of Marine Polyketide Natural Products.
    Lam, N.Y.S., Paterson, I. European Journal of Organic Chemistry 2019, XX, XXXX Link to Publication

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